1017183-06-0Relevant articles and documents
Design and synthesis of novel benzimidazole derivatives as inhibitors of hepatitis B virus
Luo, Yu,Yao, Jia-Ping,Yang, Li,Feng, Chun-Lan,Tang, Wei,Wang, Gui-Feng,Zuo, Jian-Pin,Lu, Wei
experimental part, p. 5048 - 5055 (2010/09/05)
A series of novel benzimidazole derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in the HepG2.2.15 cell line. The preliminary SAR was discussed. Compound 12a, with IC50 81.2, was the most promising compound and selected as the benchmark compound for further optimization.