10172-48-2

Upstream product

• 855691-54-2 [1]isoquinolyl-(4-methoxy-phenyl)-acetic acid amide 
• 169308-96-7 4-tosyloxy-benzylchloride 
• 123-08-0 4-hydroxy-benzaldehyde 
• 882970-92-5 1-(4-hydroxybenzyl)isoquinoline N-oxide 

Downstream Products

• 10172-49-3 1-(4-methoxybenzyl)-isoquinoline 
• 882970-92-5 1-(4-hydroxybenzyl)isoquinoline N-oxide 

Relevant academic research and scientific papers

Regioselective hydroxylation of phenols by simultaneous photochemical generation of phenol cation-radical and hydroxyl radical

Substituted phenols having pendant isoquinoline N-oxide were synthesized and their photochemical and luminiscent properties studied. Photolysis in an acid medium was found to yield the related photohydroxylation products, in a regioselective process, in a

FUNGAL CELL WALL SYNTHESIS GENE

A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed.Therefore, through the novel compounds, the present invention showed that antifungal agents having a novel mechanism, i.e. inhibiting the process that transports GPI-anchored proteins to the cell wall, could be achieved.