10172-74-4

Upstream product

• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 591-31-1 3-methoxy-benzaldehyde 
• 22105-09-5 4‐hydroxycoumarin 

Relevant academic research and scientific papers

Efficient synthesis of bis-(4-hydroxycoumarin) using sulfanilic acid as recyclable catalyst in water

A catalytic reaction between aromatic aldehydes and 4- hydroxycoumarin has been developed to form a decent range of functionalized biscoumarin skeletons in excellent yields using sulfanilic acid as reusable catalyst in aqueous media. The catalytic reactio

Heterogeneous SO3H@Fe3O4 magnetic nanocatalyst as an efficient and reusable medium for the synthesis of 3,3′-(arylmethylene)-bis-(4-hydroxycoumarin), bis-(indolyl)-methane, and 1,8-dioxo-octahydroxanthene derivatives

This work aimed to synthesize a new heterogeneous catalyst (SO3H@Fe3O4 magnetic nanoparticles) and the study of its catalytic behavior in synthesizing 3,3′-(arylmethylene)-bis-(4-hydroxycoumarin), bis-(indolyl)-methane, an

Carbon-SO3H: An efficient catalyst for the synthesis of biscoumarin under ambient reaction conditions and their in silico studies

In this article, we have established a highly promising approach for the synthesis of biscoumarins via domino Knoevenagel–Michael condensation of 4-hydroxycoumarin and aromatic aldehydes in 2:1 ratio using carbon-SO3H as a solid acid catalyst i

Aluminized Polyborate-catalyzed Environmentally Benign Solvent-free Protocol for the Synthesis of Bis-coumarin Derivatives

The present work reports, an efficient application of aluminized polyborate as a mild solid acid catalyst for the multicomponent synthesis of biologically important bis-coumarin derivatives. The one-pot synthesis of bis-coumarins involves domino Knoevenag

Green synthesis of bis-coumarin derivatives using Fe(SD)3 as a catalyst and investigation of their biological activities

A convenient, practical, green, and environmentally friendly method was developed for the synthesis of biscoumarins and corresponding tetrakis products from the reaction of 4-hydroxycoumarin and various aldehydes. The bis-coumarins were synthesized in hig

Coumarin compound, preparation method, and application of coumarin compound in preparing medicines for treating cerebral apoplexy

The invention provides a coumarin compound, a preparation method, and an application of the coumarin compound in preparing medicines for treating cerebral apoplexy. The main purpose of the invention is to provide ideal ischemic stroke (IS) brain protection medicines conforming to partial or all standards, wherein the ideal IS brain protection medicines have a multi-layer effect (such as an antioxidant effect), can non-selectively block acute IS cascade reactions caused by oxidative stress (OS), can remarkably reduce the cerebral infarction volume, do not influence the vascular tension or cause bleeding events in research processes, promotes brain tissue to metabolize toxicity substances, have slight side effects, do not need differential diagnosis before being used, and consequentially make early-stage treatment efficient and feasible.

A nano-composite of magnetite and hot-water-soluble starch: A cooperation resulting in an amplified catalytic activity on water

Bis-coumarins and xanthenes are privileged compounds with diverse pharmaceutical activities. Hence, we introduce here an efficient synthesis of 3,3′-arylmethylene-bis-(4-hydroxycoumarin-3-yl) and 1,8-dioxooctahydroxanthenes under the soft catalytic activi

Efficient synthesis of bis(indolyl)methanes, bispyrazoles and biscoumarins using 4-sulfophthalic acid

4-Sulfophthalic acid (4-H3SPA) solution 50?wt% in H2O has been effectively catalyzed the synthesis of a series of biologically relevant bis(indolyl)methanes by the electrophilic substitution of indole derivatives on aldehyde compound

BiVO4-NPs: an efficient nano-catalyst for the synthesis of biscoumarins, bis(indolyl)methanes and 3,4-dihydropyrimidin-2(1H)-ones (thiones) derivatives

BiVO4-NPs can be used as an efficient and reusable nano-catalyst for the promotion of the synthesis of biscoumarins, bis(indolyl)methanes and 3,4-dihydropyrimidin-2(1H)-ones (thiones) derivatives. The structures of the products were characteriz

Caffeine-H3PO4: a novel acidic catalyst for various one-pot multicomponent reactions

Caffeine-H3PO4 along with caffeine-HClO4 and caffeine-HNO3 have been prepared and applied for one-pot preparation of bis(indolyl) methanes, 4,4′-(arylmethylene) bis(1H-pyrazol-5-ols), 3,3′-(arylmethylene) bis(4-hydroxycoumarins), 2,4,5-trisubstituted imidazoles, 1‐amidoalkyl‐2‐naphthols, and polyhydroquinolines. The catalysts were characterized using Fourier-transform infrared (FTIR) spectroscopy, 1H and 13C nuclear magnetic resonance (NMR), powder X-ray diffraction (PXRD) analysis, thermogravimetric analysis (TGA), and liquid chromatography (LC)–mass spectroscopy (MS) techniques. The results indicated high product yield, short reaction time, facile separation of catalyst, and easy work-up procedure, suggesting that caffeine-H3PO4 can be considered to be an efficient acidic catalyst for organic transformations.