10173-58-7 Usage
Chemical structure
2-(1H-benzimidazol-2-yl)-4-fluoroaniline consists of a benzimidazole ring fused to a fluorinated aniline.
Usage in industries
It is often used in the pharmaceutical and agrochemical industries.
Purpose
The compound serves as a building block for the synthesis of various biologically active molecules.
Potential applications
It has potential applications in drug discovery and development.
Modulation of biological targets
2-(1H-benzimidazol-2-yl)-4-fluoroaniline can modulate various biological targets.
Synthesis of dyes and polymers
It is also used in the synthesis of fluorescent dyes and polymers.
Antimicrobial properties
The compound has been studied for its antimicrobial properties.
Antitumor properties
2-(1H-benzimidazol-2-yl)-4-fluoroaniline has been researched for its potential antitumor effects.
Diverse potential uses
This compound has diverse and promising potential uses in various fields, including medicine, chemistry, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 10173-58-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,1,7 and 3 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 10173-58:
(7*1)+(6*0)+(5*1)+(4*7)+(3*3)+(2*5)+(1*8)=67
67 % 10 = 7
So 10173-58-7 is a valid CAS Registry Number.
10173-58-7Relevant articles and documents
Benzimidazoquinazolines as new potent anti-TB chemotypes: Design, synthesis, and biological evaluation
Chakraborti, Asit K.,Dhameliya, Tejas M.,Jadhavar, Pradeep S.,Krishna, Vagolu Siva,Patel, Kshitij I.,Saha, Nirjhar,Sriram, Dharmarajan,Vaja, Maulikkumar D.
, (2020/03/31)
In search for new molecular entities as anti-TB agents, the benzimidazoquinazoline polyheterocyclic scaffold has been designed adopting the scaffold hopping strategy. Thirty-two compounds have been synthesized through an improved tandem decarboxylative nucleophilic addition cyclocondensation reaction of o-phenylenediamine with isatoic anhydride followed by further cyclocondensation of the intermediately formed 2-(o-aminoaryl)benzimidazole with trialkyl orthoformate/acetate. The resultant benzimidazoquinazolines were evaluated in vitro for anti-TB activity against M. tuberculosis H37Rv (ATCC27294 strain). Fourteen compounds exhibiting MIC values in the range of 0.4–6.25 μg/mL were subjected to cell viability test against RAW 264.7 cell lines and were found to be non-toxic (30% inhibition at 50 μg/mL). The active compounds were further evaluated against INH resistant Mtb strains. The most active compound 6x [MIC (H37Rv) of 0.4 μg/mL] and the compound 6d [MIC (H37Rv) of 0.78 μg/mL] were also found to be active against INH resistant Mtb strain with MIC values of 12.5 and 0.78 μg/mL, respectively.
