10173-71-4

Basic information

• Product Name: 5-chloro-2-(2-nitro-phenyl)-1H-benzoimidazole
• Synonyms: 5-chloro-2-(2-nitro-phenyl)-1H-benzoimidazole
• CAS NO: 10173-71-4
• Molecular Weight: 273.678
• Mol File: 10173-71-4.mol

Chemical Properties

• CAS DataBase Reference: 5-chloro-2-(2-nitro-phenyl)-1H-benzoimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-2-(2-nitro-phenyl)-1H-benzoimidazole(10173-71-4)
• EPA Substance Registry System: 5-chloro-2-(2-nitro-phenyl)-1H-benzoimidazole(10173-71-4)

Safety Data

• Hazardous Substances Data: 10173-71-4(Hazardous Substances Data)

Upstream product

• 95-83-0 4-Chloro-1,2-phenylenediamine 
• 552-89-6 2-nitro-benzaldehyde 

Relevant articles and documents

Synthesis and insight into the structure-activity relationships of 2-phenylbenzimidazoles as prospective anticancer agents

In order to explore and develop new anticancer agents, three series of 2-phenylbenzimidazoles,15-46, were condensed under simple and mild conditions using sodium metabisulfite as an oxidation agent and another series,47-55, were obtainedviaa reduction rea

Bentonite clay: An efficient catalyst for the synthesis of 2-substituted benzimidazoles

Benzimidazoles have been reported to have a wide range of biological and therapeutic properties. For this reason a variety of methods for their synthesis has been described, following one of the two general routes: the coupling of o-phenylenediamine and c

Method for catalytically synthesizing benzimidazole compound in water phase under microwave radiation

The invention discloses a method for catalytically synthesizing a benzimidazole compound in a water phase under microwave radiation. The method comprises the following steps: adding a catalytic amount of metal chloride, proline lithium and a substituted 2-halogenated aniline substrate, ammonia water, a benzaldehyde derivative, inorganic alkali and water into a reaction container; putting the reaction container into a microwave reaction instrument to react at certain temperature and under certain power; after certain time, decompressing and concentrating; purifying a product through a column chromatography to obtain the benzimidazole compound, wherein the metal chloride in the step is iron chloride, cobalt chloride, nickel chloride or copper chloride, the inorganic alkali in the step is sodium hydroxide, cesium carbonate, sodium carbonate, potassium hydroxide or potassium phosphate, and reaction temperature of the microwave reaction instrument is 20 DEG C to 200 DEG C. The method for preparing the benzimidazole compound, provided by the invention, is environmental-friendly, is simple and convenient to operate, is safe and cheap and is efficient. Compared with the prior art, the method has the advantages of moderate reaction conditions, simplicity in operation, high yield, safety, low cost and environmental friendliness.