10173-72-5Relevant academic research and scientific papers
Microwave-assisted one-pot synthesis of 2-(substituted phenyl)-1H- benzimidazole derivatives
Navarrete-Vazquez, Gabriel,Moreno-Diaz, Hermenegilda,Estrada-Soto, Samuel,Torres-Piedra, Mariana,Leon-Rivera, Ismael,Tlahuext, Hugo,Munoz-Muniz, Omar,Torres-Gomez, Hector
, p. 2815 - 2825 (2007)
A series of 2-(substituted phenyl)-1H-benzimidazole derivatives with various 5-and 6-position substituents (-H, -CH3, -CF3) were synthesized via microwave irradiation using a short synthetic route and Na2S2O5 as oxidant. This simple, fast, and efficient p
A facile and efficient synthesis of benzimidazole as potential anticancer agents
Hoang, Thi-Kim-Dung,Huynh, Thi-Kim-Chi,Nguyen, Thanh-Danh,Nguyen, Thi-Hong-An,Tran, Ngoc-Hoang-Son
, (2020/07/13)
Abstract: This study reports a simple process to synthesize and separate of 2-(substituted-phenyl) benzimidazole derivatives with high yield and efficiency. Specifically, by reacting ortho-phenylenediamines with benzaldehydes using sodium metabisulphite a
Solid Phase Synthesis of Biologically active Benzimidazole Derivatives Catalysed by CH3S03H-Si02 under Solvent free Condition
Datta, Arup,Roy, Sanjay
, p. 537 - 543 (2020/07/23)
A simple an expeditious method was established for the synthesis of 2-Substituted-1H-Benzimidazole derivatives at 90°C using o-phenylenediamine and different aldehydes. It has been found that a mixture of Methanesulphonic acid-Si02to be an effective catal
Water-mediated synthesis of 2-substituted benzimidazoles by boric acid and glycerol
Mukhopadhyay, Chhanda,Tapaswi, Pradip Kumar,Butcher, Ray J.
experimental part, p. 140 - 144 (2009/08/15)
A very simple, mild, and highly efficient green catalyst has been developed for the synthesis of 2-substituted benzimidazoles by treatment of substituted ortho-phenylenediamines and aldehydes in water at 80C in the presence of boric acid (5 mol-%) and glycerol (0.05 mL). This methodology has been standardized on 55 substrates, and nine new compounds have been synthesized.
Efficient method for the synthesis of benzimidazoquinazoline derivatives with three-point diversity
Saha, Biswajit,Sharma, Sunil,Kundu, Bijoy
, p. 3455 - 3470 (2008/02/13)
An efficient strategy for the preparation of a novel heterocyclic ring system of benzimidazoquinazolines with three-point diversity has been described. The compounds were obtained by treating o-phenylene diamines with o-nitrobenzaldehyde to give benzimidazoles, followed by reduction of the nitro group to give an amine. Derivatization of the resulting amine with isothiocyanates followed by in situ cyclodesulfurization at rt furnished the title compounds in high yields and purities. Copyright Taylor & Francis Group, LLC.
