1017513-51-7

Basic information

• Product Name: 5-(3,4-difluorophenyl)isoxazole-3-carboxylic acid
• Synonyms: 5-(3,4-difluorophenyl)isoxazole-3-carboxylic acid;5-(3,4-difluorophenyl)-1,2-oxazole-3-carboxylic acid
• CAS NO: 1017513-51-7
• Molecular Formula: C₁₀H₅F₂NO₃
• Molecular Weight: 225.1484064
• Mol File: 1017513-51-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(3,4-difluorophenyl)isoxazole-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3,4-difluorophenyl)isoxazole-3-carboxylic acid(1017513-51-7)
• EPA Substance Registry System: 5-(3,4-difluorophenyl)isoxazole-3-carboxylic acid(1017513-51-7)

Safety Data

• Hazardous Substances Data: 1017513-51-7(Hazardous Substances Data)

Upstream product

• 1416981-41-3 methyl 5-(3,4-difluorophenyl)isoxazole-3-carboxylate 
• 369-33-5 3',4'-difluoroacetophenone 

Downstream Products

• 1391626-06-4 (3S,6S)-4-(5-(3,4-difluorophenyl)isoxazole-3-carbonyl)-3,6-diisobutylpiperazin-2-one 

Relevant articles and documents

Synthesis and anticancer activity of heteroaromatic linked 4β-amido podophyllotoxins as apoptotic inducing agents

A series of different heteroaromatic linked 4β-amidopodophyllotoxin conjugates (16a-i, 17a-i and 18a-d) were synthesized and evaluated for anticancer activity against five human cancer cell lines. Among the series, one of the compound 17g showed significant antiproliferative activity in A549 (lung cancer) cell line. Flow cytometric analysis showed that 17g arrested the cell cycle in the G2/M phase leading to caspase-3 dependent apoptotic cell death. Further, Hoechst 33258 staining and DNA fragmentation assay also suggests that 17g induces cell death by apoptosis.