1017572-47-2

Upstream product

• 104783-88-2 ethyl 2-hydroxy-4-(methoxymethoxy)-6-methylbenzoate 
• 16740-98-0 tri-O-methyl-D-glucal 
• 55628-54-1 3,4,6-tri-O-benzyl-D-glucal 
• 2873-29-2 D-glucal triacetate 

Downstream Products

• 1017572-48-3 7-(acetyloxy)-6-(3-methylbut-2-en-1-yl)-3-oxo-2,3-dihydro-1H-isoindol-5-yl 2-hydroxy-4-(methoxymethoxy)-6-methylbenzoate 
• 1235324-90-9 C₁₅H₂₀O₅ 

Relevant academic research and scientific papers

Photolytic Studies on the Generation and Trapping of 6-Oxomethylidenecyclohexa-2,4-diene-1-one Derivatives with Various Nucleophiles

α-Oxoketenes and cyclohexadiene α-oxoketenes are reactive intermediates, particularly the latter due to their high re-aromatization potential. In this communication, we report photolytic studies on the generation of such species from 4-OMe and 4-OMOM protected resorcylate dioxinones and their trapping to give resorcylate esters and amides as well as the formation of adducts with enol-ethers as trapping reagents.

First total synthesis of sterenins A, C and D

The first total synthesis of sterenins A, C and D, potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), is described. The prenyl group was regioselectively introduced by a Claisen rearrangement, whereas the construction of an isoindolinone skeleton was accomplished by the lactamization of lactones assisted by a phenolic hydroxyl group.