1017599-17-5

Basic information

• Product Name: (3,4-difluorophenyl)[5-(hydroxymethyl)-2-pyridinyl]methanone
• Synonyms: (3,4-difluorophenyl)[5-(hydroxymethyl)-2-pyridinyl]methanone
• CAS NO: 1017599-17-5
• Molecular Weight: 249.217
• Mol File: 1017599-17-5.mol

Chemical Properties

• CAS DataBase Reference: (3,4-difluorophenyl)[5-(hydroxymethyl)-2-pyridinyl]methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (3,4-difluorophenyl)[5-(hydroxymethyl)-2-pyridinyl]methanone(1017599-17-5)
• EPA Substance Registry System: (3,4-difluorophenyl)[5-(hydroxymethyl)-2-pyridinyl]methanone(1017599-17-5)

Safety Data

• Hazardous Substances Data: 1017599-17-5(Hazardous Substances Data)

Upstream product

• 1189175-69-6 (3,4-difluorophenyl)[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]methanone 

Downstream Products

• 1017599-22-2 (E)-(3,4-difluorophenyl)[5-(hydroxymethyl)-2-pyridinyl]methanone O-(2-hydroxy-2-methylpropyl)oxime 
• 1017599-21-1 (Z)-(3,4-difluorophenyl)[5-(hydroxymethyl)-2-pyridinyl]methanone O-(2-hydroxy-2-methylpropyl)oxime 
• 1017600-80-4 C₁₄H₁₁F₂NO₄S 
• 1189175-69-6 (3,4-difluorophenyl)[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]methanone 
• 1189175-91-4 N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoro-2-(phenylsulfonyl)ethyl]-2-methylpropane-2-(S)-sulfinamide 
• 1283090-78-7 N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoroethyl]-2-methylpropane-2-(S)-sulfinamide 
• 1283090-79-8 {6-[1-amino-1-(3,4-difluorophenyl)-2,2-difluoroethyl]pyridin-3-yl}methanol 
• 1283090-80-1 1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoroethanamine 
• 1283090-81-2 N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difIuorophenyl)-2,2-difluoroethyl]acetamide 
• 1283090-76-5 N-{1-(3,4-difluorophenyl)-2,2-difluoro-1-[5-(hydroxymethyl)pyridin-2-yl]ethyl}acetamide 
• 1283090-77-6 N-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl](3,4-difluorophenyl)methylidene-2-methylpropane-2-(S)-sulfinamide 
• 1283090-90-3 N-{1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2-fluoro-2-(phenylsulfonyl)ethyl}-2-methylpropane-2-(S)-sulfinamide 
• 1283090-95-8 N-[1-(3,4-difluorophenyl)-2,2-difluoro-1-{5-[(7-fluoro-1H,1'H-spiro[furo[3,4-c]pyridine-3,4'-piperidin]-1'-yl)methyl]pyridin-2-yl}ethyl]acetamide 
• 1283090-91-4 C₁₇H₁₆F₄N₂O₄S 

Relevant articles and documents

DIARYL KETIMINE DERIVATIVE HAVING ANTAGONISM AGAINST MELANIN-CONCENTRATING HORMONE RECEPTOR

[Problems] To provide an antagonist of a melanin-concentrating hormone receptor, which is useful as a medicine for a central nervous system disease, a cardiovascular disease or a metabolic disease. [Means for Solving Problems] The antagonist comprises, as an active ingredient, a compound represented by the formula (I) wherein R1a and R1b independently represent a hydrogen atom or a C1-6 alkyl group; R2a, R2b, R3a and R3b independently represent a hydrogen atom, a C1-6 alkyl group, or the like; Y represents H or —OH; Z represents —OR8, or the like; R8 represents a hydrogen atom, a C1-6 alkyl group which may have a substituent, or the like; R9a and R9b independently represent a hydrogen atom, a C1-6 alkyl group, or the like; Ar1 represents an aromatic carbon ring group, or an aromatic heteroring group; Ar2 represents a group produced by removing two hydrogen atoms from an aromatic carbon ring, or the like; and the ring group A represents an unsaturated heteroring group.

Discovery of novel diarylketoxime derivatives as selective and orally active melanin-concentrating hormone 1 receptor antagonists

Optimization of the lead 2a led to the identification of a novel diarylketoxime class of melanin-concentrating hormone 1 receptor (MCH-1R) antagonists. Our focus was directed toward improvement of hERG activity and metabolic stability. The representative derivative 4b showed potent and dose-dependent body weight reduction in diet-induced obese (DIO) C57BL/6J mice after oral administration. The synthesis and structure-activity relationships of the novel diarylketoxime MCH-1R antagonists are described.

DIARYL KETIMINE DERIVATIVE

Provided is a compound of a formula (I): [wherein R1a and R1b are the same or different, representing a hydrogen atom, etc.; R2a and R2b are the same or different, representing a hydrogen atom, etc., or R2a and R2b, taken together, form -CH2CH2-, R3a and R3b are the same or different, representing a hydrogen atom, etc.; or R3a and R3b, taken together, form - CH2CH2-etc.; Y1 and Y2 represent -C(R)2-, etc.; Z represents OR, NR2, etc.; R represents a hydrogen atom, a C1-6 alkyl group, etc.; Ar1 represents a 6-membered aromatic carbocyclic group, etc.; Ar2 represents a 6-membered aromatic carbocyclic group, etc; A3 represents a 6-membered aromatic carbocyclic group etc.]. The compound is useful as a medicine for central disorders, cardiovascular disorders, metabolic disorders.