10176-63-3

Upstream product

• 4241-12-7 6-methyl-5-phenylpyrid-2-one-3-carbonitrile 

Downstream Products

• 108611-26-3 6-Methyl-2-morpholin-4-yl-5-phenyl-nicotinonitrile 
• 108611-23-0 2-(2-Hydroxy-ethylamino)-6-methyl-5-phenyl-nicotinonitrile 
• 108611-29-6 2-(2-Hydroxy-ethoxy)-6-methyl-5-phenyl-nicotinonitrile 
• 132187-71-4 methyl 3-amino-6-methyl-5-phenylthieno[2,3-b]pyridine-2-carboxylate 
• 108611-24-1 2-(2-Hydroxy-propylamino)-6-methyl-5-phenyl-nicotinonitrile 
• 116228-70-7 6-methyl-5-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 108611-31-0 2-(2-Methoxy-ethoxy)-6-methyl-5-phenyl-nicotinonitrile 
• 128882-36-0 1,4-bis<3-cyan-5-phenyl(pyrid-2-yl)>piperazin 
• 108611-33-2 6-Methyl-5-phenyl-2-piperazin-1-yl-nicotinonitrile 

Relevant academic research and scientific papers

IMIDAZOPYRIDINES, COMPOSITIONS AND USE

1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones having an aryl or heteroaryl group in the 6-position, useful as phosphodiesterase inhibitors, are prepared by reacting a 2-amino-5-(aryl or heteroaryl)pyridine-3-carboxylic acid with diphenylphosphoryl azide. The compounds are of the formula where R1 and R3 are hydrogen or lower-alkyl, R5 is lower-alkyl or fluorinated lower-alkyl, and Ar is 4-or 3-pyridinyl, or N-oxides thereof, or phenyl or substituted phenyl.

Imidazopyridines, their preparation and use

Novel 1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones having an aryl or heteroaryl group in the 6-position, useful as phosphodiesterase inhibitors, are prepared by reacting a 2-amino-5-(aryl or heteroaryl)pyridine-3-carboxylic acid with diphenylphosphoryl azide. The compounds are of the formula STR1 where R1 and R3 are hydrogen or lower-alkyl, R5 is lower-alkyl or fluorinated lower-alkyl, and Ar is 4- or 3-pyridinyl, or phenyl or substituted phenyl.