101767-28-6

Basic information

• Product Name: 2-METHYL-THIAZOLE-4-CARBOXYLIC ACID HYDRAZIDE
• Synonyms: BUTTPARK 48\08-63;2-METHYL-4-THIAZOLECARBOHYDRAZIDE;2-METHYLTHIAZOLE-4-CARBOHYDRAZIDE;2-METHYL-THIAZOLE-4-CARBOXYLIC ACID HYDRAZIDE;4-Thiazolecarboxylicacid,2-methyl-,hydrazide(9CI);2-methyl-1,3-thiazole-4-carbohydrazide;2-Methyl-1,3-thiazole-4-carboxylic acid hydrazide, 4-(Hydrazinocarbonyl)-2-methyl-1,3-thiazole;4-Thiazolecarboxylic acid, 2-Methyl-, hydrazide
• CAS NO: 101767-28-6
• Molecular Formula: C₅H₇N₃OS
• Molecular Weight: 157.19
• Product Categories: AMIDE
• Mol File: 101767-28-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 126-129
• Appearance: /
• Density: 1.355
• Refractive Index: 1.607
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 11.12±0.10(Predicted)
• CAS DataBase Reference: 2-METHYL-THIAZOLE-4-CARBOXYLIC ACID HYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-THIAZOLE-4-CARBOXYLIC ACID HYDRAZIDE(101767-28-6)
• EPA Substance Registry System: 2-METHYL-THIAZOLE-4-CARBOXYLIC ACID HYDRAZIDE(101767-28-6)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22
• Safety Statements: 22-36/37/39
• Hazardous Substances Data: 101767-28-6(Hazardous Substances Data)

Usage

General Description

2-Methyl-thiazole-4-carboxylic acid hydrazide is a chemical compound with the molecular formula C6H8N4O2S. It is a hydrazide derivative of thiazole carboxylic acid, and it is used in the synthesis of various pharmaceuticals and biologically active compounds. 2-Methyl-thiazole-4-carboxylic acid hydrazide is known for its antimicrobial and antifungal properties, and it has been studied for its potential applications in the treatment of various diseases. Additionally, it is also used as a precursor in the synthesis of other organic compounds and is a valuable intermediate in organic chemistry.

InChI:InChI=1/C5H7N3OS/c1-3-7-4(2-10-3)5(9)8-6/h2H,6H2,1H3,(H,8,9)

Upstream product

• 6436-59-5 ethyl 2-methylthiazole-4-carboxylate 

Downstream Products

• 1429558-36-0 (S)-4-(7-(2,4-dimethoxybenzyl)-8-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-2-methylthiazole 
• 1429560-58-6 (S)-(8-methyl-3-(2-methylthiazol-4-yl)-5,6-dihydro-[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl)(4-(thiophen-2-yl)phenyl)methanone 
• 1429557-03-8 (3-(2-methylthiazol-4-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)(4-(thiophen-2-yl)phenyl)methanone 
• 1429607-62-4 (R)-4-(7-(2,4-dimethoxybenzyl)-8-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-2-methylthiazole 
• 1429556-99-9 (R)-(8-methyl-3-(2-methylthiazol-4-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)(4-(thiophen-2-yl)phenyl)methanone 

Relevant articles and documents

FLUOROALKYL-OXADIAZOLES AND USES THEREOF

Provided herein are compounds identified as inhibitors of HDAC6 activity that can be used to treat various diseases and disorders.

NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF

The present invention relates to novel compounds of Formula I and their use in therapeutic treatments. The invention further relates to a novel chiral synthesis of 5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines using N-sp3 protective groups. The invention also provides intermediates for use in the synthesis of compounds of Formula I.