101767-93-5

Basic information

• Product Name: 1-<(4-methylphenyl)sulfonyl>-3-piperidinol 4-methylbenzenesulfonate ester
• Synonyms: 1-<(4-methylphenyl)sulfonyl>-3-piperidinol 4-methylbenzenesulfonate ester
• CAS NO: 101767-93-5
• Molecular Weight: 409.527
• Mol File: 101767-93-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-<(4-methylphenyl)sulfonyl>-3-piperidinol 4-methylbenzenesulfonate ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-<(4-methylphenyl)sulfonyl>-3-piperidinol 4-methylbenzenesulfonate ester(101767-93-5)
• EPA Substance Registry System: 1-<(4-methylphenyl)sulfonyl>-3-piperidinol 4-methylbenzenesulfonate ester(101767-93-5)

Safety Data

• Hazardous Substances Data: 101767-93-5(Hazardous Substances Data)

Upstream product

• 768-32-1 trimethylphenylsilane 
• 81097-24-7 N-tosyl-(4-pentenyl)amine 
• 6859-99-0 3-hydroxypiperazine 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 111952-40-0 Bis-(4-fluoro-phenyl)-[1-(toluene-4-sulfonyl)-piperidin-3-yl]-acetonitrile 
• 1025728-48-6 (+/-)-1-(4-toluenesulfonyl)-piperidine-3-carbonitrile 
• 111951-97-4 {1-[3-(4-Acetyl-2-methoxy-phenoxy)-propyl]-piperidin-3-yl}-bis-(4-fluoro-phenyl)-acetonitrile 
• 111952-41-1 Bis-(4-fluoro-phenyl)-piperidin-3-yl-acetonitrile 

Relevant articles and documents

Gold-catalysed oxyarylation of styrenes and mono- and gem-disubstituted olefins facilitated by an iodine(III) oxidant

1-Hydroxy-1,2-benziodoxol-3(1H)-one (IBA) is an efficient terminal oxidant for gold-catalysed, three-component oxyarylation reactions. The use of this iodine(III) reagent expands the scope of oxyarylation to include styrenes and gem-disubstituted olefins, substrates that are incompatible with the previously reported Selectfluor-based methodology. Diverse arylsilane coupling partners can be employed, and in benzotrifluoride, homocoupling is substantially reduced. In addition, the IBA-derived co-products can be recovered and recycled. The I's have it: The unprecedented use of an iodine(III) reagent as the terminal oxidant for gold-catalysed oxyarylation allows the substrate scope to be significantly expanded; in addition to monosubstituted olefins, styrenes and gem-disubstituted olefins are well tolerated (see scheme). With benzotrifluoride as solvent, unproductive homodimerisation of the arylsilane coupling partner is effectively suppressed. Copyright

Muscarinic receptor antagonists

Compounds of the formula STR1 and the pharmaceutically acceptable salts thereof, wherein: Y is a direct link, --CH 2 --, --(CH 2) 2 --, --CH 2 O-- or --CH 2 S--; R is --CN or --CONH 2 ; and R 1 is STR2 where X and X 1 are each independently O or CH 2 ; and m is 1, 2 or 3, are muscarinic receptor antagonists useful in the treatment of diseases and conditions associated with the altered motility and/or tone of smooth muscle, such as irritable bowel syndrome.