101767-94-6

Basic information

• Product Name: 4-Piperidinol, 1-[(4-methylphenyl)sulfonyl]-, 4-methylbenzenesulfonate (ester)
• CAS NO: 101767-94-6
• Molecular Formula: C19H23NO5S2
• Molecular Weight: 409.527
• Mol File: 101767-94-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-Piperidinol, 1-[(4-methylphenyl)sulfonyl]-, 4-methylbenzenesulfonate (ester)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Piperidinol, 1-[(4-methylphenyl)sulfonyl]-, 4-methylbenzenesulfonate (ester)(101767-94-6)
• EPA Substance Registry System: 4-Piperidinol, 1-[(4-methylphenyl)sulfonyl]-, 4-methylbenzenesulfonate (ester)(101767-94-6)

Safety Data

• Hazardous Substances Data: 101767-94-6(Hazardous Substances Data)

Upstream product

• 5382-16-1 4-HYDROXYPIPERIDINE 
• 98-59-9 p-toluenesulfonyl chloride 
• 41979-39-9 4-piperidone hydrochloride 
• 80213-12-3 1-[(4-methylbenzene)-sulfonyl]-4-piperidinol 
• 6457-49-4 4-piperidinemethanol 

Downstream Products

• 93431-41-5 1-(4-toluenesulfonyl)-piperidine-4-carbonitrile 
• 111952-30-8 α,α-diphenyl-4-piperidineacetonitrile 
• 111952-11-5 2-{1-[3-(4-Acetyl-2-methoxy-phenoxy)-propyl]-piperidin-4-yl}-2,2-diphenyl-acetamide; compound with (E)-but-2-enedioic acid 
• 111952-10-4 {1-[3-(4-Acetyl-2-methoxy-phenoxy)-propyl]-piperidin-4-yl}-diphenyl-acetonitrile; compound with oxalic acid 
• 103887-43-0 α,α-diphenyl-4-piperidineacetamide 
• 289890-80-8 4-iodo-1-[(4-methylphenyl)sulfonyl]piperidine 
• 347885-68-1 4-bromo-1-tosylpiperidine 
• 111952-35-3 α,α-bis(4-fluorophenyl)-1-<(4-methylphenyl)sulfonyl>-4-piperidineacetonitrile 
• 111951-85-0 {1-[3-(4-Acetyl-2-methoxy-phenoxy)-propyl]-piperidin-4-yl}-bis-(4-fluoro-phenyl)-acetonitrile 
• 111952-36-4 α,α-bis(4-fluorophenyl)-4-piperidineacetonitrile 

Relevant articles and documents

Nickel-Catalyzed Cyanation of Unactivated Alkyl Sulfonates with Zn(CN)2

Cyanation of unactivated primary and secondary alkyl mesylates with Zn(CN)2 catalyzed by nickel has been developed. The reaction provides an efficient route for the synthesis of alkyl nitriles with wide substrate scope, good functional group tolerance, and compatibility with heterocyclic compounds. Mechanistic studies indicate that alkyl iodide generated in situ serves as the reactive intermediate and the gradual release of alkyl iodide is crucial for the success of the reaction.

Nitrilase-catalyzed enantioselective synthesis of pyrrolidine- And piperidinecarboxylic acids

The enantioselective synthesis of the nonproteinogenic amino acids β-proline and nipecotic acids from their readily available nitriles is achieved in high enantiomeric excess by commercially available nitrilases. The presented procedure comprises not more than 4 steps, thus considerably reducing the multiple steps generally required. Amide formation is also observed for specific heterocyclic nitriles.

Synthesis and Antiallergy Activity of 4-(Diarylhydroxymethyl)-1-piperidines and Structurally Related Compounds

A series of 4-(diarylhydroxymethyl)-1-piperidines was synthesized and evaluated for antiallergy activity.Several analogues had potent activity in the passive foot anaphylaxis (PFA) assay, an IgE-mediated model useful in the detection of compounds possessing antiallergic activity.In particular 1--1-piperidinyl>propoxy>-3-methoxyphenyl>ethanone (1, AHR-5333) was more potent than oxatomide and terfenadine in this assay.