10177-15-8

Basic information

• Product Name: 5-phenylpyridine-3-carboxamide
• Synonyms: 5-phenylpyridine-3-carboxamide;5-PhenylnicotinaMide
• CAS NO: 10177-15-8
• Molecular Formula: C₁₂H₁₀N₂O
• Molecular Weight: 198
• Mol File: 10177-15-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-phenylpyridine-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-phenylpyridine-3-carboxamide(10177-15-8)
• EPA Substance Registry System: 5-phenylpyridine-3-carboxamide(10177-15-8)

Safety Data

• Hazardous Substances Data: 10177-15-8(Hazardous Substances Data)

Usage

General Description

5-phenylpyridine-3-carboxamide is a chemical compound with the molecular formula C12H9N3O. It is also known by its trade name, Fenazon. 5-phenylpyridine-3-carboxamide is commonly used in the pharmaceutical industry as a building block for the synthesis of various pharmaceutical agents and drugs. It has also been identified as a potential inhibitor for a number of protein kinases, making it a promising candidate for the development of new cancer treatments. Additionally, 5-phenylpyridine-3-carboxamide has demonstrated anti-inflammatory and analgesic properties, making it valuable for the treatment of various inflammatory conditions and pain management. Overall, this chemical compound has a wide range of potential applications in the pharmaceutical and medical fields.

Upstream product

• 35590-37-5 5-bromopyridine-3-carbonitrile 
• 98-80-6 phenylboronic acid 
• 28733-43-9 5-bromonicotinamide 

Relevant articles and documents

A method for preparing the amide compounds

The invention discloses a method for preparing an amide compound. The method includes the following specific step: raw materials of a cyano compound and a boric acid compound are heated for a cyan hydrolysis reaction and a carbon-carbon coupling reaction with a mixed solvent of a protic solvent and a non protonic solvent as the reaction medium, in the air atmosphere and in the presence of alkali and a palladium compound catalyst, so as to prepare the amide compound. The novel method for preparing amide compound disclosed by the invention avoids the usage of an oxidant in the prior art, so as to effectively inhibit the excessive hydrolysis of cyano group, avoid further hydrolysis of amide into carboxylic acid, and greatly improve the reaction yield of the amide compound; and the method can be carried out simultaneously with the carbon-carbon coupling reaction to prepare more amide compounds, and has great market value and economic benefit for industrial production of amide compounds.

Efficient coupling of heteroaryl halides with arylboronic acids in the presence of a palladium-tetraphosphine catalyst

Cis, cis, cis-1,2,3,4-tetrakis(diphenylphosphinomethyl) cyclopentane: ·1/2[PdCl(C3H5)]2 system catalyses the Suzuki cross-coupling of heteroaryl halides with a range of arylboronic acids with very high ratio substrate/catalyst in good yields. Substrates such as pyridines, quinolines, thiophenes, an indole, pyrimidines or a furane have been used successfully.