1017967-61-1

Basic information

• Product Name: ⁽⁹⁹⁾Tc((O₂CCH₂)2N(CH₂CH₂N(CH₂CO₂))2CH₂C(O)OCH₂C₆H₃(OCH₂C₆H₂(O(CH₂CH₂O)3CH₃)3)2)^(1-)*Na⁽¹⁺⁾=C₇₇H₁₂₁N₃O₃₆⁽⁹⁹⁾TcNa
• CAS NO: 1017967-61-1
• Molecular Weight: 1786.8
• Mol File: 1017967-61-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ⁽⁹⁹⁾Tc((O₂CCH₂)2N(CH₂CH₂N(CH₂CO₂))2CH₂C(O)OCH₂C₆H₃(OCH₂C₆H₂(O(CH₂CH₂O)3CH₃)3)2)^(1-)*Na⁽¹⁺⁾=C₇₇H₁₂₁N₃O₃₆⁽⁹⁹⁾TcNa(CAS DataBase Reference)
• NIST Chemistry Reference: ⁽⁹⁹⁾Tc((O₂CCH₂)2N(CH₂CH₂N(CH₂CO₂))2CH₂C(O)OCH₂C₆H₃(OCH₂C₆H₂(O(CH₂CH₂O)3CH₃)3)2)^(1-)*Na⁽¹⁺⁾=C₇₇H₁₂₁N₃O₃₆⁽⁹⁹⁾TcNa(1017967-61-1)
• EPA Substance Registry System: ⁽⁹⁹⁾Tc((O₂CCH₂)2N(CH₂CH₂N(CH₂CO₂))2CH₂C(O)OCH₂C₆H₃(OCH₂C₆H₂(O(CH₂CH₂O)3CH₃)3)2)^(1-)*Na⁽¹⁺⁾=C₇₇H₁₂₁N₃O₃₆⁽⁹⁹⁾TcNa(1017967-61-1)

Safety Data

• Hazardous Substances Data: 1017967-61-1(Hazardous Substances Data)

Upstream product

• 13718-28-0 sodium [99Tc]pertechnetate 
• 1017967-81-5 (HO₂CCH₂)2NCH₂CH₂N(CH₂CO₂H)CH₂CH₂N(CH₂CO₂H)CH₂C(O)OCH₂C₆H₃(OCH₂C₆H₂(O(CH₂CH₂O)3CH₃)3)2 

Relevant articles and documents

Synthesis and characterization of a highly stable dendritic catechol-tripod bearing technetium-99m

The synthesis and preliminary biological tests (in vitro toxicity, in vitro stability) of new Tc(iii)-radiolabelled dendro-chelates are presented. A dendritic 99mTc chelate 1 derived from a pre-organized tripodal tris-catecholamide exhibits a kinetic stability by far more important than its corresponding diethylenetriamine pentaacetic acid (DTPA) homologue 2. This permitted an assessment of the real impact of the pre-organized tripodal structure on kinetic inertness (and thus toxicity), an important issue to address when considering in vivo applications. Radiolabelling was performed using the stannous chloride reduction method; while DTPA-homologue 2 showed a high radiolabelling efficiency (96% radiolabelling yield after 30 min), tripodal complex 1 induced a 93% complexation yield after 45 min. In contrast, radiocomplex 1 derived from the most rigid and organized structure has a higher kinetic stability than 2. Indeed, while dissociation of 2 reached 50% after 1 h 30 min in physiological media like phosphate buffer saline (PBS) and bovine serum albumin (BSA), over 80% of 1 remained stable during the half-life of the radionucleide (6.02 h for 99mTc). Measurements of the cell leakage resulting from membrane damage of neuronal cells treated with increasing concentrations of dendritic ligand 16, together with pictures of treated neurons after staining, showed no detectable toxicity.