1018-71-9

Usage

Uses

Used in Antifungal Applications:
PYRROLNITRIN is used as an antifungal agent for its ability to inhibit the growth and proliferation of fungi, making it a valuable component in the development of antifungal products.
Used in Microbiology:
PYRROLNITRIN from Pseudomonas cepacia has been utilized as a standard in the detection of pyrrolnitrin in Serratia marcescens cell culture extract. This application highlights its importance in the field of microbiology for accurate identification and analysis of specific bacterial strains.

Biochem/physiol Actions

Pyrrolnitrin blocks the terminal electron transport between succinate or reduced NADH and coenzyme Q. In mitochondria preparations of S. cerevisiae, the antibiotic inhibited succinate oxidase, NADH oxidase, succinate cythochrome C reductase, and NADH-cytochrome C reductase. Pyrrolnitrin is involved in many cellular processes such as oxidative stress, electron transport, DNA and RNA synthesis.

InChI:InChI=1/C10H6Cl2N2O2/c11-8-3-1-2-6(10(8)14(15)16)7-4-13-5-9(7)12/h1-5,13H

Upstream product

• 1126425-93-1 3-chloro-4-(3'-chloro-2'-nitrophenyl)-N-(TIPS)pyrrole 
• 16386-65-5 4-(3'-chloro-2'-aminophenyl)-3-chloropyrrole 
• 153-97-9 7-chloro-D/L-tryptophan 

Downstream Products

• 106191-76-8 2,4-Dichloro-6-[4,5-dichloro-3-nitro-1-(2,3,3-triiodo-allyl)-1H-pyrrol-2-ylmethyl]-phenol 
• 87427-22-3 1-(2',3',3'-triiodoallyl)-3-chloro-4-(3-chloro-2-nitrophenyl)pyrrole 

Related news

PYRROLNITRIN (cas 1018-71-9) is more essential than phenazines for Pseudomonas chlororaphis G05 in its suppression of Fusarium graminearum07/21/2019

Fusarium graminearum is the major causal agent of Fusarium head blight (FHB) disease in cereal crops worldwide. Infection with this fungal phytopathogen can regularly cause severe yield and quality losses and mycotoxin contamination in grains. In previous other studies, one research group report...detailed

Relevant academic research and scientific papers

Mechanistic studies on the conversion of arylamines into arylnitro compounds by aminopyrrolnitrin oxygenase: identification of intermediates and kinetic studies

(Chemical Equation Presented) Rieske business! The Rieske N-oxygenase, aminopyrrolnitrin oxygenase (PrnD), catalyzes the unusual oxidation of arylamines to arylnitro compounds. Kinetic analysis has confirmed that PrnD catalyzes the conversion of the substrate pABA (4-aminobenzylamine) through at least three consecutive reactions: two monooxygenation steps and one dehydrogenation step (see scheme).

Synthesis of pyrrolnitrin and related halogenated phenylpyrroles

A general approach to halogenated arylpyrroles, including the antifungal natural product pyrrolnitrin, is described using newly synthesized halogenated pyrroles and 2,6-disubstituted nitrobenzenes or 2,6-disubstituted anilines.

Antifungal compositions

This invention relates to an antimycotic composition comprising pyrrolnitrin and at least one member selected from the group consisting of lanoconazole, butenafine or a salt thereof, and an allylamine-series antimycotic agent as active ingredients, which composition has a potent antimycotic action as compared with its component drugs used each independently and is not only of great use in the treatment of dermatophytosis such as tinea,tinea imbricata, tinea favosa, tinea profunda,etc. and fungal infections such as candidiasis ofcutaneous mucosa, candidiasis profunda,etc. but also useful from the standpoint of alleviation of side effects and improvement in the patient's compliance.

3-Imino-1,2,4-benzotriazine-1-oxides

New 3-Imino-1,2,4-benzotriazine-1-oxides of formula I SPC1 wherein R represents an alkyl, alkenyl or haloalkyl radical, a phenyl or aralkyl radical optionally substituted by alkyl, alkoxy, haloalkyl, halogen or hydroxy, X and Y each independently represent hydrogen, halogen, an alkyl or alkoxy radical, or one of the two symbols represents a phenoxy or phenylsulphonyl radical optionally substituted by halogen, alkyl, haloalkyl and/or alkoxy which are active against harmful microorganisms are disclosed.