101814-74-8

Basic information

• Product Name: 6-azido-uridine
• Synonyms: 6-azido-uridine
• CAS NO: 101814-74-8
• Molecular Formula: C₉H₁₁N₅O₆
• Molecular Weight: 285.21354
• Mol File: 101814-74-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-azido-uridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-azido-uridine(101814-74-8)
• EPA Substance Registry System: 6-azido-uridine(101814-74-8)

Safety Data

• Hazardous Substances Data: 101814-74-8(Hazardous Substances Data)

Upstream product

• 908354-36-9 6-azido-5'-O-(t-butyldimethylsilyl)-2',3'-O-isopropylideneuridine 
• 142682-82-4 5'-O-(terrt-butyldimethylsilyl)-2',3'-O-isopropylidene-6-iodouridine 
• 102147-76-2 5'-O-(t-butyldimethylsilyl)-2',3'-O-isopropylideneuridine 
• 58-96-8 uridine 
• 362-43-6 2',3'-O-isopropylideneuridine 

Downstream Products

• 27960-35-6 6-amino-uridine 

Relevant articles and documents

NMR-based conformational analysis of 2′,6-disubstituted uridines and antiviral evaluation of new phosphoramidate prodrugs

Six novel phosphoramidate prodrugs of uridine analogues, with structural modifications introduced at the 6- and 2′,6-positions, have been prepared and evaluated for selective antiviral activity against hepatitis C virus, as well as other positive-stranded RNA viruses. An analysis of the conformational properties of the parent nucleosides was carried out using two-dimensional NMR spectroscopy based experiments, highlighting a 3′-endo (North) sugar puckering preference and syn orientation.

PYRIMIDINE DERIVATIVES AS ANTICANCER AGENTS

The present invention includes methods of treating or preventing cancer by administering an effective amount of 6-substituted pyrimidine derivatives of the Formula I to a subject need thereof: