10182-82-8 Usage
General Description
2-amino-3-(3-hydroxy-4-oxo-pyridin-1-yl)propanoic acid, also known as kynurenine, is an amino acid that plays a crucial role in the metabolism of tryptophan. It is a metabolite of the kynurenine pathway, which is responsible for the breakdown of tryptophan, an essential amino acid. Kynurenine has been shown to have neuroprotective and immunomodulatory properties and is involved in the regulation of inflammation and oxidative stress. Additionally, kynurenine has been implicated in various neurological and psychiatric disorders, such as depression, schizophrenia, and neurodegenerative diseases. It is also considered a potential target for the development of novel therapies for these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 10182-82-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,1,8 and 2 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 10182-82:
(7*1)+(6*0)+(5*1)+(4*8)+(3*2)+(2*8)+(1*2)=68
68 % 10 = 8
So 10182-82-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H10N2O4/c9-5(8(13)14)3-10-2-1-6(11)7(12)4-10/h1-2,4-5,12H,3,9H2,(H,13,14)
10182-82-8Relevant articles and documents
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Adams,Johnson
, p. 705,707 (1949)
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Biomimetic Synyhesis of Heterocyclic β-Substituted Alanines by Pyridoxal 5'-Phosphate-Catalyzed Chemical Reactions
Murakoshi, Isamu,Ikegami, Fumio,Yoneda, Yoshihiro,Ihara, Harumi,Sakata, Kumiko,Koide, Chiharu
, p. 1473 - 1478 (2007/10/02)
Several heterocyclic β-substituted alanines were biomimetically synthesized by incubating 0.1M acetate buffer solution containing the appropriate heterocyclic compound and O-acetylserine or serine in the presence of pyridoxal 5'-phosphate (PLP) and metal ions.This PLP-catalyzed chemical reaction depends upon pH, metal ions and temperature.The addition of Ga3+, Fe3+ or Al3+ enhanced the rate of synthesis.The optimum of the various reaction conditions of this biomimetic method is described.Keywords - biomymetic synthesis; amino acid synthesis; heterocyclic β-substituted alanine; non-protein amino acid; O-acetylserine; N-heterocyclic compound; pyridoxal 5'-phosphate; metal ion
