10184-68-6Relevant articles and documents
α-Hydroxyphosphonates as intermediates in the Kabachnik–fields reaction: New proof of their reversible formation
Keglevich, Gy?rgy,Rádai, Zita
, (2020)
The rearrangement of dimethyl α-hydroxybenzylphosphonate to the corresponding benzylphosphate in the presence of an alkali carbonate in acetone under phase transfer catalytic conditions was accompanied by the formation of dimethyl α–hydroxyisopropylphosph
New process for the production of 1-hydroxyalkane phosphonic esters
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Paragraph 0037; 0038, (2017/05/30)
The present invention relates to a novel process for preparing a 1-hydroxyalkane phosphonic ester derivative known to be useful for an intermediate of a phosphorus-based flame retardant and for a medicine, such as an antiviral agent. According to the conventional processes, there are problems in that an excessive amount of solid byproducts is produced, a reaction solvent is used undesirably, an agitation-related problem occurs due to an increase in viscosity of a reaction mixture caused by the interaction with a catalyst, and a limitation in reaction is present because only an activated aromatic ketone can be used for reaction. To solve the problems, the present invention provides a method for preparing the target compound by making a phosphite compound react with a conventional carbonyl compound in the presence of a mixed catalyst of potassium fluoride and potassium hydroxide. It is thought that the method contributes to fine chemistry and pharmaceutical sources.
Intramolecular nucleophilic catalysis and the exceptional reactivity of N-benzyloxycarbonyl α-aminophosphonochloridates
Cullis, Paul M.,Harger, Martin J.P.
, p. 1538 - 1543 (2007/10/03)
The intramolecular nucleophilic catalysis and the exceptional reactivity of N-benzyloxycarbonyl α-aminophosphonochloridates were discussed. It was found that N-benzyloxycarbonyl derivatives of α-aminophosphonochloridates were highly reactive because of in
