10184-69-7

Basic information

• Product Name: Pregna-1,4,9(11)-triene-3,20-dione, 17,21-dihydroxy-
• CAS NO: 10184-69-7
• Molecular Formula: C₂₁H₂₆O₄
• Molecular Weight: 342.435
• Mol File: 10184-69-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Pregna-1,4,9(11)-triene-3,20-dione, 17,21-dihydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Pregna-1,4,9(11)-triene-3,20-dione, 17,21-dihydroxy-(10184-69-7)
• EPA Substance Registry System: Pregna-1,4,9(11)-triene-3,20-dione, 17,21-dihydroxy-(10184-69-7)

Safety Data

• Hazardous Substances Data: 10184-69-7(Hazardous Substances Data)

Usage

General Description

Pregna-1,4,9(11)-triene-3,20-dione, 17,21-dihydroxy- is a synthetic steroid hormone that is commonly known as hydrocortisone. It is used as a medication for various conditions, including inflammatory disorders, allergic reactions, and certain types of cancer. Hydrocortisone works by reducing inflammation and suppressing the immune response. It is available in various forms, including creams, ointments, and oral tablets, and is commonly used to treat skin conditions such as eczema and dermatitis. Additionally, hydrocortisone is used in certain medical procedures to reduce swelling and inflammation. However, prolonged use of this chemical can lead to various side effects, including thinning of the skin, easy bruising, and increased risk of infection.

Upstream product

• 7753-60-8 anecortave 

Downstream Products

• 52-21-1 prednisolone 21-acetate 
• 50-24-8 prednisolon 

Relevant articles and documents

Microbial conversion of pregna-4,9(11)-diene-17α,21-diol-3,20-dione acetates by Nocardioides simplex VKM Ac-2033D

The conversion of pregna-4,9(11)-diene-17α,21-diol-3,20-dione 21-acetate (I) and 17,21-diacetate (VI) by Nocardioides simplex VKM Ac-2033D was studied. The major metabolites formed from I were identified as pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 21-acetate (II) and pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione (IV). Pregna-4,9(11)-diene-17α,21-diol-3,20-dione (III) and pregna-1,4,9(11)-triene-17α,20β,21-triol-3-one (V) were formed in minorities. Biotransformation products formed from VI were pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 17,21-diacetate (VII), pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 21-acetate (II), pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione (IV), pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 17-acetate (VIII), pregna-1,4,9(11)-triene-17α,20β,21-triol-3-one (V). The conversion pathways were proposed including 1(2)-dehydrogenation, deacetylation, 20β-reduction and non-enzymatic migration of acyl group from position 17 to 21. The conditions providing predominant accumulation of pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 21-acetate (II) from I and pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 17-acetate (VIII) from VI in a short-term biotransformation were determined.