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10184-98-2

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10184-98-2 Usage

General Description

Diethyl (1H-indol-3-ylmethyl)propanedioate is a chemical compound with the molecular formula C19H23NO4. It is a diester formed from the condensation of indole-3-carboxaldehyde and malonic acid, and contains a 1H-indol-3-ylmethyl group. diethyl (1H-indol-3-ylmethyl)propanedioate may be used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It has potential applications in drug design and development due to its indole moiety, which is found in many biologically active compounds. Furthermore, its ester functionality makes it a versatile intermediate for the synthesis of various organic molecules. Further research and testing may reveal additional uses and potential applications for diethyl (1H-indol-3-ylmethyl)propanedioate.

Check Digit Verification of cas no

The CAS Registry Mumber 10184-98-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,1,8 and 4 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 10184-98:
(7*1)+(6*0)+(5*1)+(4*8)+(3*4)+(2*9)+(1*8)=82
82 % 10 = 2
So 10184-98-2 is a valid CAS Registry Number.

10184-98-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name diethyl 2-(1H-indol-3-ylmethyl)propanedioate

1.2 Other means of identification

Product number -
Other names diethyl 2-(indol-3-yl)methylmalonate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10184-98-2 SDS

10184-98-2Relevant articles and documents

Convenient Synthesis of 6,7,12,13-Tetrahydro-5H-Cyclohepta[2,1-b:3,4-b’]diindole Derivatives Mediated by Hypervalent Iodine (III) Reagent

Peng, Lei,Zhang, Xiaofei,Yang, Chunhao

, (2019)

Bisindolyl alkaloids represent a large family of natural and synthetic products that display various biological activities. Among the bisindole compounds, 6,7,12,13-tetrahydro-5H-cyclohepta[2,1-b:3,4-b’]diindoles have received little attention. Only two methods have been developed for the construction of the 6,7,12,13-tetrahydro-5H-cyclohepta[2,1-b:3,4-b’]diindole scaffold thus far, including the classical Fischer indole synthesis conducted by reacting indole-fused cycloheptanone and hydrazines, and the condensation reaction to build the seven-membered ring. Here, we report for the first time a new route to synthesize 6,7,12,13-tetrahydro-5H-cyclohepta[2,1-b:3,4-b’]diindoles through intramolecular oxidative coupling of 1,3-di(1H-indol-3-yl)propanes in the presence of PIFA, DDQ and TMSCl with moderate to excellent yields.

Substitution of the Dimethylamino Group in Gramines and One-Pot Cyclization to Tetrahydro-β-carbolines Using a Triazine-Based Activating Agent

Fujita, Hikaru,Nishikawa, Riho,Sasamoto, Ozora,Kitamura, Masanori,Kunishima, Munetaka

, p. 8380 - 8391 (2019)

A new method for the substitution of 3-[(dimethylamino)methyl]indoles (gramines) with malonate-based nucleophiles was developed using 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) as the activating agent for the dimethylamino group. The reaction was completed in 1.5-6 h at room temperature in the presence of a tert-amine base and lithium salt. CDMT afforded superior results to methyl iodide, a common activating agent for the dimethylamino group in Mannich bases, particularly in the reactions of 1-substituted gramines. The reactivity of the possible intermediates, bis(indol-3-ylmethyl)dimethylammonium salts, was examined to obtain mechanistic insights on the reaction. This substitution method with CDMT enabled the sequential transformation of gramines: substitution with (N-alkylidene)aminomalonates followed by the Pictet-Spengler reaction under acidic conditions afforded 1,2,3,4-tetrahydro-β-carboline derivatives in one pot.

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Snyder et al.

, p. 200,203 (1944)

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