101856-92-2

Upstream product

• 463-71-8 thiophosgene 
• 29026-74-2 2-isopropoxy-phenylamine 
• 748771-95-1 2-isopropoxyaniline hydrochloride 

Downstream Products

• 1415233-05-4 N-[2-(2-Isopropoxy-phenylamino)-4'-methyl-[4,5']bithiazolyl-2'-yl]-acetamide 
• 1176665-23-8 (2-Isopropoxy-phenyl)-thiourea 

Relevant academic research and scientific papers

METHODS OF INHIBITING PRO MATRIX METALLOPROTEINASE ACTIVATION

This invention relates to methods for preventing, treating or ameliorating an MMP9 and/or MMP13 mediated syndrome, disorder or disease comprising administering to a subject in need thereof an effective amount of a compound listed in the examples section of this specification, or a form, composition or medicament thereof. Disorders treated and/or prevented include rheumatoid arthritis.

TRICYCLIC INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION

This invention relates to tricycle I and its therapeutic and prophylactic uses, wherein the variables C1, C2, Z1, Z2, Q, J, R1, and R3 are defined in the specification. Disorders treated and/or prevented include rheumatoid arthritis.