1018673-42-1

Basic information

• Product Name: cyclopentyl 2-cyclohexyl-2-((6-(3-(hydroxyamino)-3-oxopropyl)pyridin-3-yl)methylamino)acetate
• Synonyms: cyclopentyl 2-cyclohexyl-2-((6-(3-(hydroxyamino)-3-oxopropyl)pyridin-3-yl)methylamino)acetate;HDAC-IN-3;GSK3117391A;GSK3117391
• CAS NO: 1018673-42-1
• Molecular Formula: C22H33N3O4
• Molecular Weight: 403.51512
• EINECS: -0
• Mol File: 1018673-42-1.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: cyclopentyl 2-cyclohexyl-2-((6-(3-(hydroxyamino)-3-oxopropyl)pyridin-3-yl)methylamino)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: cyclopentyl 2-cyclohexyl-2-((6-(3-(hydroxyamino)-3-oxopropyl)pyridin-3-yl)methylamino)acetate(1018673-42-1)
• EPA Substance Registry System: cyclopentyl 2-cyclohexyl-2-((6-(3-(hydroxyamino)-3-oxopropyl)pyridin-3-yl)methylamino)acetate(1018673-42-1)

Safety Data

• Hazardous Substances Data: 1018673-42-1(Hazardous Substances Data)

Usage

Description

Hdac-IN-3, also known as GSK3117391, is a potent histone deacetylase (HDAC) inhibitor with an IC50 value of less than 100 nM in HeLa nuclear extracts. It effectively inhibits the growth of U937 and HUT cancer cells, with IC50 values of less than 330 nM. Hdac-IN-3 plays a crucial role in regulating gene expression and has potential applications in various fields due to its ability to modulate histone acetylation.

Uses

Used in Pharmaceutical Industry:
Hdac-IN-3 is used as an HDAC inhibitor for the development of targeted cancer therapies. Its ability to inhibit the growth of cancer cells, particularly U937 and HUT, makes it a promising candidate for the treatment of various types of cancer. Hdac-IN-3 modulates histone acetylation, which can lead to the regulation of gene expression and the suppression of tumor growth.
Used in Research and Development:
Hdac-IN-3 is used as a research tool for studying the role of HDAC enzymes in cellular processes and their potential as therapeutic targets. Its potent inhibitory activity allows researchers to investigate the effects of HDAC inhibition on gene expression, cell proliferation, and other cellular functions.
Used in Drug Discovery and Development:
Hdac-IN-3 serves as a lead compound in the development of new drugs targeting HDAC enzymes. Its potent inhibitory activity and selectivity make it an attractive starting point for the design and synthesis of novel HDAC inhibitors with improved pharmacological properties and therapeutic potential.
Used in Epigenetic Studies:
Hdac-IN-3 is used as a chemical probe in epigenetic research to understand the role of histone deacetylation in gene regulation, cellular differentiation, and disease progression. By studying the effects of HDAC inhibition, researchers can gain insights into the complex interplay between epigenetic modifications and cellular processes.