1018676-02-2 Usage
Uses
Different sources of media describe the Uses of 1018676-02-2 differently. You can refer to the following data:
1. {3-[2-(DiMethylaMino)ethyl]-5-[(pyrrolidine-1-yl)sulfonylMethyl]-1H-indol-1-yl}Methanol is an impurity of Almotriptan (A575201), a serotonin 5HT1B /1D-receptor agonist used for treatment of migraine.
2. 3-[2-(Dimethylamino)ethyl]-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-1-methanol is an impurity of Almotriptan (A575201), a serotonin 5HT1B /1D-receptor agonist used for treatment of migraine.
Check Digit Verification of cas no
The CAS Registry Mumber 1018676-02-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,1,8,6,7 and 6 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1018676-02:
(9*1)+(8*0)+(7*1)+(6*8)+(5*6)+(4*7)+(3*6)+(2*0)+(1*2)=142
142 % 10 = 2
So 1018676-02-2 is a valid CAS Registry Number.
1018676-02-2Relevant articles and documents
METHOD FOR THE PREPARATION OF HIGH PURITY ALMOTRIPTAN
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Page/Page column 10, (2009/01/24)
A method for the preparation and purification of the substance of formula (I), i.e. 3-[2- (dimethylamino)ethyl]-5-(1-pyrrolidinylsulfonylmethyl)-1H-indole, which comprises (a) conversion of 4-(1-pyrrolidinylsulfonylmethyl)phenylhydrazine of formula (III) by reaction with an organic or inorganic acid to a salt that is insoluble or poorly soluble in water, which is converted to 3-(2-aminoethyl)-5-(1-pyrrolidinylsulfonylmethyl)indole of formula (VII), which is further converted without isolation to a solution of the almotriptan base, which provides a crystalline salt of almotriptan with an organic or inorganic acid; (b) conversion of the salt of almotriptan to the almotriptan base, which separates from the solution in the crystalline form; (c) purification of the almotriptan base by crystallization from an organic solvent.
