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1018678-48-2

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1018678-48-2 Usage

General Description

Benzoic acid, 1-(difluoromethyl)-methyl ester is a chemical compound with the molecular formula C9H9F2O2. It is an ester derivative of benzoic acid, which is commonly used as a food preservative and as an intermediate in the production of various organic compounds. The addition of a difluoromethyl group to the methyl ester enhances its stability and potential applications. Benzoic acid,1-(difluoromethyl)-methyl ester may have uses in the pharmaceutical and agricultural industries due to its unique properties and structure. However, it is important to handle this chemical with caution as it may pose potential hazards if not properly managed.

Check Digit Verification of cas no

The CAS Registry Mumber 1018678-48-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,1,8,6,7 and 8 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1018678-48:
(9*1)+(8*0)+(7*1)+(6*8)+(5*6)+(4*7)+(3*8)+(2*4)+(1*8)=162
162 % 10 = 2
So 1018678-48-2 is a valid CAS Registry Number.

1018678-48-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 2-(difluoromethyl)benzoate

1.2 Other means of identification

Product number -
Other names methyl 2-difluoromethylbenzoate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1018678-48-2 SDS

1018678-48-2Relevant articles and documents

Accessing Difluoromethylated and Trifluoromethylated cis-Cycloalkanes and Saturated Heterocycles: Preferential Hydrogen Addition to the Substitution Sites for Dearomatization

Zhang, Xue,Ling, Liang,Luo, Meiming,Zeng, Xiaoming

, p. 16785 - 16789 (2019)

Reported here is a straightforward process in which a cyclic (alkyl)(amino)carbene/Rh catalyst system facilitates the preferential addition of hydrogen to the substitution sites of difluoromethylated and trifluoromethylated arenes and heteroarenes, leading to dearomative reduction. This strategy enables the diastereoselective synthesis of cis-difluoromethylated and cis-trifluoromethylated cycloalkanes and saturated heterocycles, and even allows formation of all-cis multi-trifluoromethylated cyclic products with a defined equatorial orientation of the di- and trifluoromethyl groups. Deuterium-labeling studies indicate that hydrogen preferentially attacks the substitution sites of planar arenes, resulting in dearomatization, possibly with heterogeneous Rh as the reactive species, followed by either reversible or irreversible hydrogen addition to the nonsubstitution sites.

SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS

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Paragraph 0738; 0739, (2017/04/04)

Provided herein are novel substituted bicyclic aza-heterocycle sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

PYRROLOTRIAZINE INHIBITORS OF IRAK4 ACTIVITY

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Page/Page column 44, (2016/09/26)

The present invention relates to pyrrolotriazine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.

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