1018690-17-9

Basic information

• Product Name: Benzenecarbothioic acid, 2,5-difluoro-, hydrazide, hydrochloride (1:1)
• Synonyms: Benzenecarbothioic acid, 2,5-difluoro-, hydrazide, hydrochloride (1:1);2,5-difluorobenzothiohydrazidehydrochloride;EOS-61822
• CAS NO: 1018690-17-9
• Molecular Formula: C₇H₆F₂N₂S*ClH
• Molecular Weight: 224.6586864
• Mol File: 1018690-17-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenecarbothioic acid, 2,5-difluoro-, hydrazide, hydrochloride (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenecarbothioic acid, 2,5-difluoro-, hydrazide, hydrochloride (1:1)(1018690-17-9)
• EPA Substance Registry System: Benzenecarbothioic acid, 2,5-difluoro-, hydrazide, hydrochloride (1:1)(1018690-17-9)

Safety Data

• Hazardous Substances Data: 1018690-17-9(Hazardous Substances Data)

Upstream product

• 885060-36-6 2,5-difluoro-benzothiohydrazide 
• 1018690-18-0 2-(2,5-difluoro-phenylcarbonothioylthio)acetic acid 
• 1021853-64-4 C₇H₄F₂S₂ 
• 1259928-70-5 C₁₂H₁₄F₂N₂O₂S 
• 1146210-65-2 C₈H₆F₂S₂ 

Downstream Products

• 1018783-69-1 tert-butyl 2-(5-(2,5-difluorophenyl)-2-phenyl-2,3-dihydro-1,3,4-thiadiazol-2-yl)ethyl-carbamate 
• 1018690-41-9 2-((5-(2,5-difluorophenyl)-2-phenyl-2,3-dihydro-1,3,4-thiadiazol-2-yl)methoxy)acetonitrile 
• 1018690-43-1 C₂₃H₂₅F₂N₃O₄S 
• 1018690-42-0 [5-(2,5-difluoro-phenyl)-3-((S)-2-methoxy-propionyl)-2-phenyl-2,3-dihydro-[1,3,4]thiadiazol-2-ylmethoxy]-acetonitrile 
• 1146210-67-4 C₁₈H₁₄F₃N₃O₃S 
• 1146210-69-6 C₁₈H₁₄F₃N₃O₃S 
• 1146210-68-5 C₁₈H₁₄F₃N₃O₃S 
• 1146210-71-0 C₁₈H₁₄F₃N₃O₃S 
• 1146210-70-9 C₁₈H₁₄F₃N₃O₃S 
• 1146211-11-1 C₂₃H₂₃F₃N₄O₄S 

Relevant articles and documents

Synthesis, determination of absolute configuration, and biological evaluation of spiro-fused thiadiazoline inhibitors of kinesin spindle protein (KSP)

A facile and highly convergent synthesis of biologically active spiro-fused thiadiazoline KSP inhibitors is reported. The highlights of the synthesis include the Michael reaction and cyclization of thiosemicarbazone to 1,3,4-thiadiazoline. This chemistry lends itself to the preparation of (+)-2, a potent and orally bioavailable anti-cancer agent, and to the development of a structure-activity relationship program.

SPIRO-CONDENSED 1, 3, 4-THIADIAZOLE DERIVATIVES FOR INHIBITING KSP KINESIN ACTIVITY

The present invention relates to compounds of Formula (I), below, (wherein X, R1, R2, R3, p, E, ring A, and ring B are as defined herein). The present invention also relates to compositions (including pharmaceutically acceptable compositions) comprising t