1018699-97-2

Upstream product

• 70501-66-5 phenyl-(5-phenyl-2H-[1,2,3]triazol-4-yl)-methanone 
• 1018698-84-4 4-phenyl-5-(1-phenylvinyl)-2H-1,2,3-triazole 

Downstream Products

• 882300-84-7 (3-benzyl-5-phenyl-3H-1,2,3-triazol-4-yl)(phenyl)methanol 
• 1052184-84-5 (2-benzyl-5-phenyl-2H-1,2,3-triazol-4-yl)(phenyl)methanol 
• 1052185-30-4 ethyl 2-(4-(hydroxy(phenyl)methyl)-5-phenyl-2H-1,2,3-triazol-2-yl)acetate 
• 1052185-29-1 (2-(2-chloroethyl)-5-phenyl-2H-1,2,3-triazol-4-yl)(phenyl)methanol 
• 1078126-49-4 4-benzyl-5-phenyl-2H-1,2,3-triazole 

Relevant academic research and scientific papers

Facile synthesis and stereo-resolution of chiral 1,2,3-triazoles

We describe herein the first facile synthesis of chiral triazoles through side chain functionalization. Readily available C-vinyl triazoles were used as starting materials, followed by sequential epoxidation, rearrangement and reduction to give the corresponding hydroxyl-triazoles. The CalB lipase catalyzed kinetic resolution gave enantiomerically pure (>99% ee) chiral triazoles in excellent yield. These new chiral TAs were also successfully applied as ligands in asymmetric addition of diethylzinc to aldehydes.

One step cascade synthesis of 4,5-disubstituted-1,2,3-(NH)-triazoles

(Chemical Equation Presented) A Lewis base-catalyzed three-component cascade reaction was developed for the synthesis of 4,5-disubstituted-1,2,3-(NH) -triazoles. More than 25 new (NH)-triazoles were prepared in good to excellent yields under mild conditions. The availability of the C-4 vinyl group allows easy conversion into other triazole derivatives.