1018705-40-2Relevant academic research and scientific papers
Synthesis of new fluorogenic cyanine dyes and incorporation into RNA fluoromodules
Constantin, Tudor P.,Silva, Gloria L.,Robertson, Kelly L.,Hamilton, Tamara P.,Fague, Kaitlin,Waggoner, Alan S.,Armitage, Bruce A.
, p. 1561 - 1564 (2008)
A new fluorogenic cyanine dye was synthesized and found to have low fluorescence quantum yield in fluid solution and in the presence of double-stranded DNA but 80-fold enhanced fluorescence in viscous glycerol solution. An RNA aptamer selected for binding to the new dye exhibits K d = 87 nM and 60-fold fluorescence enhancement. The dye-aptamer pair is a fluoromodule that can be incorporated into fluorescent sensors and labels.
