1018812-91-3

Basic information

• Product Name: 8-chloro-1,7-naphthyridin-4(1H)-one
• Synonyms: 8-chloro-1,7-naphthyridin-4(1H)-one
• CAS NO: 1018812-91-3
• Molecular Formula: C8H5ClN2O
• Molecular Weight: 180.5911
• Mol File: 1018812-91-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-chloro-1,7-naphthyridin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-chloro-1,7-naphthyridin-4(1H)-one(1018812-91-3)
• EPA Substance Registry System: 8-chloro-1,7-naphthyridin-4(1H)-one(1018812-91-3)

Safety Data

• Hazardous Substances Data: 1018812-91-3(Hazardous Substances Data)

Usage

General Description

8-chloro-1,7-naphthyridin-4(1H)-one is a chemical compound that belongs to the family of naphthyridine derivatives. It contains a chlorine atom and a cyclic structure composed of a naphthyridine ring with a ketone functional group at the 4th position. 8-chloro-1,7-naphthyridin-4(1H)-one has shown potential pharmacological activities, including anti-viral and anti-cancer properties. It is commonly used as a building block for the synthesis of various pharmaceutical compounds and is also studied for its potential therapeutic applications. Additionally, it is of interest in the field of medicinal chemistry due to its structural features and potential biological activities.

InChI:InChI=1S/C8H5ClN2O/c9-8-7-5(1-3-11-8)6(12)2-4-10-7/h1-4H,(H,10,12)

Upstream product

• 1018812-90-2 5-[[(2-chloropyridin-3-yl)amino]methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 6298-19-7 2-chloro-3-aminopyridine 

Downstream Products

• 60122-51-2 1,7-naphthyridin-4(1H)-one 

Relevant articles and documents

NOVEL BICYCLIC COMPOUND OR SALT THEREOF

Provided is a novel bicyclic compound which has an HSP90 inhibitory effect and a carcinostatic effect. Also provided is a pharmaceutical agent which is based on the HSP90 inhibitory effect and is useful in the prevention and/or treatment of a disease involving HSP90, particularly, cancer. The present invention provides a compound represented by the following general formula (I) or a salt thereof wherein at least one of X1, X2, X3, and X4 represents N or N-oxide and the rest thereof are the same or different and each represent C—R2; any one or two of Y1, Y2, Y3, and Y4 represent C—R4 and the rest thereof are the same or different and each represent CH or N;R1 represents an optionally substituted monocyclic or bicyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, S, and O;R2 represents a hydrogen atom, an optionally substituted alkyl group having 1 to 6 carbon atoms etc.;R3 represents a hydrogen atom, —CO—R5 etc.;R4 represents a hydrogen atom, —CO—R6, —N(R7)(R8) etc.;R5 represents a hydroxyl group, an amino group etc.;R6 represents a hydroxyl group etc.;R7 and R8 are the same or different and each represent a hydrogen atom, an optionally substituted alkyl group having 1 to 6 carbon atoms etc.; and R9 represents an optionally substituted cycloalkyl group having 3 to 7 carbon atoms etc.