1018895-06-1 Usage
General Description
7-Methoxy-1H-benzimidazol-2-amine, also known as CI-994, is a chemical compound that belongs to the benzimidazole class. It is a potent and selective inhibitor of class I histone deacetylases (HDACs), enzymes that are involved in the regulation of gene expression. CI-994 has shown potential as an anti-cancer agent, with studies suggesting that it can induce cell cycle arrest and apoptosis in cancer cells. Additionally, CI-994 has been investigated for its potential in treating neurodegenerative diseases and inflammatory conditions. Its ability to modulate gene expression and epigenetic regulation makes CI-994 a promising candidate for further research and development in the field of therapeutics.
Check Digit Verification of cas no
The CAS Registry Mumber 1018895-06-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,1,8,8,9 and 5 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1018895-06:
(9*1)+(8*0)+(7*1)+(6*8)+(5*8)+(4*9)+(3*5)+(2*0)+(1*6)=161
161 % 10 = 1
So 1018895-06-1 is a valid CAS Registry Number.
1018895-06-1Relevant articles and documents
JAK-2 MODULATORS AND METHODS OF USE
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Page/Page column 132, (2008/06/13)
This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention
