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1018898-77-5

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1018898-77-5 Usage

General Description

The chemical compound, with the IUPAC name "(3aS,5R,6R,6aS)-6-((tert-butyldiMethylsilyl)oxy)-2,2-diMethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carbaldehyde", is a derivative of furo[2,3-d][1,3]dioxole. It contains a carbonyl group, a tetrahydrofuran ring, and a tert-butyldimethylsilyl group. (3aS,5R,6R,6aS)-6-((tert-butyldiMethylsilyl)oxy)-2,2-diMethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carbaldehyde is commonly used in organic synthesis as a protecting group for aldehydes and ketones, due to the stability and ease of removal of the tert-butyldimethylsilyl group. It can also be used as an intermediate for the synthesis of various organic compounds and pharmaceuticals. The presence of the tetrahydrofuran ring in the structure can also impart unique chemical and biological properties to the compound.

Check Digit Verification of cas no

The CAS Registry Mumber 1018898-77-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,1,8,8,9 and 8 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1018898-77:
(9*1)+(8*0)+(7*1)+(6*8)+(5*8)+(4*9)+(3*8)+(2*7)+(1*7)=185
185 % 10 = 5
So 1018898-77-5 is a valid CAS Registry Number.

1018898-77-5Downstream Products

1018898-77-5Relevant articles and documents

NOVEL SGLT INHIBITORS

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Page/Page column 56-57, (2013/02/28)

The present invention relates to novel compounds of Formula (I), their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula (I), their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of Formula (I) and methods of treating or preventing one or more conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2).

INHIBITORS OF SODIUM GLUCOSE CO-TRANSPORTER 2 AND METHODS OF THEIR USE

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Page/Page column 22, (2008/06/13)

Compounds and pharmaceutical compositions comprising them are disclosed that may be useful for the treatment of diseases and disorders such as diabetes and obesity.

Synthesis and antiproliferative activity of some 4′-C-hydroxymethyl α- and -β-D-arabino-pentofuranosyl pyrimidine nucleosides

Griffon,Montgomery,Secrist III

, p. 649 - 652 (2007/10/03)

A suitably protected 4-C-hydroxymethyl-arabino-pentofuranose was prepared and condensed with the following nucleobases: uracil, 5-fluorouracil and thymine. The corresponding cytosine and 5-fluorocytosine derivatives have also been obtained respectively from the uracil and 5-fluorouracil nucleosides. Separation of the anomeric mixtures followed by deprotection afforded the target compounds that were found to be non-cytotoxic to CCRF-CEM leukemia cells.

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