1018940-24-3

Basic information

• Product Name: C₂₈H₂₉FN₄O₇
• CAS NO: 1018940-24-3
• Molecular Weight: 552.559
• Mol File: 1018940-24-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₈H₂₉FN₄O₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₂₉FN₄O₇(1018940-24-3)
• EPA Substance Registry System: C₂₈H₂₉FN₄O₇(1018940-24-3)

Safety Data

• Hazardous Substances Data: 1018940-24-3(Hazardous Substances Data)

Upstream product

• 960314-41-4 N-(tert-butyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide 
• 112811-77-5 1-cyclopropyl-6,7-difluoro-1,4-dihydro-5-nitro-8-methoxy-4-oxoquinoline-3-carboxylic acid 

Relevant articles and documents

Synthesis and antimycobacterial evaluation of newer 1-cyclopropyl-1,4-dihydro-6-fluoro-7-(substituted secondary amino)-8-methoxy-5-(sub)-4-oxoquinoline-3-carboxylic acids

Thirty-four newer 1-cyclopropyl-1,4-dihydro-6-fluoro-7-(substituted secondary amino)-8-methoxy-5-(sub)-4-oxoquinoline-3-carboxylic acids were synthesized from 1,2,3,4-tetrafluoro benzene and evaluated for in vitro and in vivo antimycobacterial activities against Mycobacterium tuberculosis H37Rv (MTB), multi-drug resistant M. tuberculosis (MDR-TB) and Mycobacterium smegmatis (MC2) and also tested for the ability to inhibit the supercoiling activity of DNA gyrase. Among the synthesized compounds, 7-(1-(4-methoxybenzyl)-3,4,5,6,7,8-hexahydroisoquinolin-2(1H)-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-5-nitro-4-oxoquinoline-3-carboxylic acid (13n) was found to be the most active compound in vitro with MIC of 0.16 and 0.33 μM against MTB and MDR-TB, respectively. In the in vivo animal model 13n decreased the bacterial load in lung and spleen tissues with 2.54 and 2.92 - log10 protections, respectively, at the dose of 50 mg/kg body weight. Compound 13n also inhibited the supercoiling activity of mycobacterial DNA gyrase with IC50 of 30.0 μg/ml.