101906-26-7

Basic information

• Product Name: (4S)-4-<(2R)-2-hydroxy-3-phenylthiopropyl>-2,2-dimethyl-1,3-dioxolane
• CAS NO: 101906-26-7
• Molecular Weight: 268.377
• Mol File: 101906-26-7.mol

Chemical Properties

• CAS DataBase Reference: (4S)-4-<(2R)-2-hydroxy-3-phenylthiopropyl>-2,2-dimethyl-1,3-dioxolane(CAS DataBase Reference)
• NIST Chemistry Reference: (4S)-4-<(2R)-2-hydroxy-3-phenylthiopropyl>-2,2-dimethyl-1,3-dioxolane(101906-26-7)
• EPA Substance Registry System: (4S)-4-<(2R)-2-hydroxy-3-phenylthiopropyl>-2,2-dimethyl-1,3-dioxolane(101906-26-7)

Safety Data

• Hazardous Substances Data: 101906-26-7(Hazardous Substances Data)

Upstream product

• 100-68-5 methyl-phenyl-thioether 
• 32233-44-6 2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]acetaldehyde 

Downstream Products

• 101977-99-5 (4S)-4-<(2S,7R)-(4E)-8-benzyloxy-2-hydroxy-5,7-dimethyloct-4-en-1-yl>-2,2-dimethyl-1,3-dioxolane 
• 101906-28-9 (4S)-4-<(2R,7R)-(4E)-8-benzyloxy-2-hydroxy-5,7-dimethyloct-4-en-1-yl>-2,2-dimethyl-1,3-dioxolane 
• 114125-39-2 4-Nitro-benzoic acid (E)-(1S,6R)-7-benzyloxy-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-4,6-dimethyl-hept-3-enyl ester 
• 101906-31-4 (E)-(2S,4R,9R)-10-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-((5S,6R)-5,6-dimethyl-5,6-dihydro-4H-pyran-2-yl)-7,9-dimethyl-dec-6-en-2-ol 
• 101906-29-0 (2S,4R,9R)-(6E)-1,2-epoxy-10-benzyloxy-7,9-dimethyl-4-(dimethyl-t-butylsilyloxy)dec-6-ene 
• 114092-15-8 (2S,4R,9R)-(6E)-10-benzyloxy-7,9-dimethyldec-6-ene-1,2,4-triol 
• 114092-17-0 (2S,4R,9R)-(6E)-10-benzyloxy-1,2-epoxy-7,9-dimethyldec-6-ene-4-ol 
• 101906-32-5 (2S,4S,6S,8R,9S)-2-<(5R)-(2E)-6-Benzyloxy-3,5-dimethyl-2-hexen-1-yl>-8,9-dimethyl-4-hydroxy-1,7-dioxaspiro<5.5>undecane 
• 101906-21-2 (2R,4R,6S,8R,9S)-2-<(5R)-(2E)-6-benzyloxy-3,5-dimethyl-hex-2-en-1-yl>-8,9-dimethyl-4-(dimethyl-t-butylsilyloxy)-1,7-dioxaspiro<5.5>undecane 

Relevant articles and documents

The 3,4-Dihydro-2H-pyran Approach to (+)-Milbemycin β3. Part 2. An Improved Synthesis of (2R,4S,6S,8R,9S)-2--8,9-dimethyl-4-(dimethyl-t-butylsilyloxy)-1,7-dioxaspiroundecane

A more efficient synthesis of the title compound (2), previously used in a total synthesis of (+)-milbemycin β3 (1), is described.The key step in the sequence involves a nucleophilic cleavage of the oxirane (4) by the organocuprate derived from