1019107-63-1Relevant academic research and scientific papers
Ligandless microwave-assisted Pd/Cu-catalyzed direct arylation of oxazoles
Besselievre, Francois,Mahuteau-Betzer, Florence,Grierson, David S.,Piguel, Sandrine
, p. 3278 - 3280 (2008)
(Chemical Equation Presented) An efficient microwave-assisted palladium/copper co-mediated direct arylation of oxazoles with aryl bromides under ligandless conditions has been developed. The method is functional group tolerant and provides rapid access to medicinally relevant compounds in good yields. Coupled to the van Leusen oxazole ring synthesis, this methodology is illustrated by an expedient two-step synthesis of the four 2,5-diaryloxazole alkaloids texamine, texaline, balsoxin, and O-Me-halfordinol from commercially available starting materials.
Palladium-catalyzed direct arylations of heteroarenes with tosylates and mesylates
Ackermann, Lutz,Althammer, Andreas,Fenner, Sabine
supporting information; experimental part, p. 201 - 204 (2009/04/10)
(Chemical Equation Presented) A toss up: A highly active palladium complex enabled the first direct arylation of heteroarenes through C-H bond functionalization using tosylates or mesylates as electrophiles with ample scope.
C-H bond activation: A versatile protocol for the direct arylation and alkenylation of oxazoles
Besselievre, Francois,Lebrequier, Sabrina,Mahuteau-Betzer, Florence,Piguel, Sandrine
experimental part, p. 3511 - 3518 (2010/02/28)
The versatile palladium, complex Pd(PPh3)4 catalyses both direct arylation and alkenylation of oxazoles efficiently. The method is regioselective and stereospecific with respect to bromoalkenes and tolerates a wide range of functional groups.
