1019375-35-9Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of 4-H pyran derivatives as antimicrobial and anticancer agents
Reddy, Thatikonda Narendar,Ravinder, Mettu,Bikshapathi, Raktani,Sujitha, Pombala,Kumar, C. Ganesh,Rao, Vaidya Jayathirtha
, p. 2832 - 2844 (2017/10/06)
A series of pyran derivatives (5–27) were synthesized in good yields by utilizing Baylis–Hillman chemistry and were further investigated for their in vitro anticancer, antibacterial, and antifungal activities. Most of the tested compounds exhibited promis
Substrate evaluation of rhodococcus erythropolis SET1, a nitrile hydrolysing bacterium, demonstrating dual activity strongly dependent on nitrile sub-structure
Coady, Tracey M.,Coffey, Lee V.,O'Reilly, Catherine,Lennon, Claire M.
supporting information, p. 1108 - 1116 (2015/02/19)
Assessment of Rhodococcus erythropolis SET1, a novel nitrile hydrolysing bacterial isolate, has been undertaken with 34 nitriles, 33 chiral and 1 prochiral. These substrates consist primarily of β-hydroxy nitriles with varying alkyl and aryl groups at the β position and containing in several compounds different substituents α to the nitrile. In the case of β-hydroxy nitriles without substitution at the α position, acids were the major products obtained, along with recovered nitrile after biotransformation, as a result of suspected nitrilase activity of the isolate. Unexpectedly, amides were found to be the major hydrolysis product when the β-hydroxy nitriles possessed a vinyl group at this position. To probe this behaviour further, additional related substrates were evaluated containing electron-withdrawing groups at the α position, and amide was also observed upon biotransformation in the presence of SET1. Therefore this novel isolate has also demonstrated NHase activity with nitriles that appears to be substrate-dependent.
Triphosgene mediated chlorination of Baylis-Hillman adducts
Thatikonda, Narender Reddy,Chebolu, Naga Sesha Sai Pavan Kumar,Budde, Mahendar,Vaidya, Jayathirtha Rao
body text, p. 513 - 519 (2012/07/30)
An efficient method for the preparation of allyl chlorides from Baylis-Hillman adducts has been developed using triphosgene/pyridine system. This method is best illustrated by its advantages like operational simplicity, excellent yields, short reaction ti
