1019484-11-7

Basic information

• Product Name: prop-2-en-1-yl({[3-(trifluoromethyl)phenyl]methyl})amine
• Synonyms: prop-2-en-1-yl({[3-(trifluoromethyl)phenyl]methyl})amine
• CAS NO: 1019484-11-7
• Molecular Formula: C₁₁H₁₂F₃N
• Molecular Weight: 215.21
• Mol File: 1019484-11-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: prop-2-en-1-yl({[3-(trifluoromethyl)phenyl]methyl})amine(CAS DataBase Reference)
• NIST Chemistry Reference: prop-2-en-1-yl({[3-(trifluoromethyl)phenyl]methyl})amine(1019484-11-7)
• EPA Substance Registry System: prop-2-en-1-yl({[3-(trifluoromethyl)phenyl]methyl})amine(1019484-11-7)

Safety Data

• Hazardous Substances Data: 1019484-11-7(Hazardous Substances Data)

Usage

General Description

N-(3-(trifluoromethyl)benzyl)prop-2-en-1-amine is a chemical compound with the molecular formula C11H11F3N. It is an amine containing a trifluoromethyl group attached to a benzyl ring, and a propenyl group attached to the amine functional group. N-(3-(trifluoromethyl)benzyl)prop-2-en-1-amine is used in organic synthesis and pharmaceutical research due to its potential as a building block for the synthesis of various bioactive molecules. It has also been studied for its potential pharmacological properties, including as a potential anticancer agent and as a ligand for various receptors in the central nervous system. However, further research and testing is needed to fully understand its potential applications and effects.

Upstream product

• 2740-83-2 3-(TRIFLUOROMETHYL)BENZYLAMINE 
• 106-95-6 allyl bromide 
• 107-11-9 1-amino-2-propene 

Downstream Products

• 1382449-41-3 C₁₈H₂₀F₃NO₃ 
• 1382449-69-5 C₁₆H₁₆F₃NO₃ 
• 1382448-87-4 N-hydroxy-3-[2-oxo-1-(3-trifluoromethylbenzyl)-2,5-dihydro-1H-pyrrol-3-yl]propionamide 

Relevant articles and documents

Nickel(II) Catalyzed Hydroboration: A Route to Selective Reduction of Aldehydes and N-Allylimines

A cationic [(iminophosphine)nickel(allyl)]+ complex was found to be sufficiently electrophilic to activate aldehydes and N-allylimines to undergo hydroboration with pinacolborane (HBpin) under mild reaction conditions. The catalyst displayed excellent selectivity toward aldehydes in the presence of ketones. A wide variety of functional groups were tolerated, including halogens, NO2, CN, OMe, and alkenes for both aldehydes and imines. Electron-rich substrates were found to be significantly more reactive than their electron poor counterparts, a feature that was correlated to their enhanced ability to coordinate to the Lewis acidic nickel center.

Selective hydrosilylation of N-allylimines using a (3-iminophosphine)palladium precatalyst

Hydrosilylation utilizing a (3-iminophosphine)palladium catalyst leads to the selective reduction of the imine unit of allylimines. Successful reduction of twenty-five different substituted aromatic and alkyl allylimines demonstrated the scope and selecti

Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors: Part II

Histone deacetylases (HDACs) are involved in post-translational modification and epi-genetic expression, and have been the intriguing targets for treatment of cancer. In previous study, we reported synthesis and the biological preliminary results of γ-lactam based HDAC inhibitors. Based on the previous results, smaller γ-lactam core HDAC inhibitors are more active than the corresponding series of larger δ-lactam based analogues and the hydrophobic and bulky cap groups are required for better potency which decreased microsomal stability. Thus, γ-lactam analogues with methoxy, trifluoromethyl groups of ortho-, meta-, para-positions of cap group were prepared and evaluated their biological potency. Among them, trifluoromethyl analogues, which have larger lipophilicity, showed better HDAC inhibitory activity than other analogues. In overall, lipophilicity leads to increase hydrophobic interaction between surface of HDAC active site and HDAC inhibitor, improves HDAC inhibitory activity.