101959-15-3Relevant articles and documents
Palladium-catalyzed intra-and intermolecular C-H arylation using mesylates: Synthetic scope and mechanistic studies
Ferguson, Devin M.,Rudolph, Stacey R.,Kalyani, Dipannita
, p. 2395 - 2401 (2014/07/21)
This paper describes the development of Pd-catalyzed inter-and intramolecular direct arylation using mesylates. Furthermore, a sequential mesylation/arylation protocol using phenols as substrates is described. These transformations are general with respect to the electronics of the C-H substrates and allow for the synthesis of diverse heterocyclic motifs in good yields. Both arenes and heteroarenes efficiently participate in these reactions. Preliminary mechanistic studies are presented for both inter-and intramolecular arylations.
94. Synthesen von Dibenzodioxin-2,3-chinonen, einschliesslich der Ecklonochinone A und B sowie der Isoecklonochinone A und B
Luetolf, Walter Leo,Prewo, Roland,Bieri, Jost H.,Ruedi, Peter,Eugester, Conrad Hans
, p. 860 - 881 (2007/10/02)
Syntheses of Dibenzodioxin-2,3-quinones Including the Ecklonoquinones A and B and the Isoecklonoquinones A and B.Oxidation of monomesyloxy-substituted pyrocatechols with MnO2 in toluene using phase-transfer conditions leads in high yield to monomesyloxy-substituted dibenzodioxin-2,3-quinones with loss of one mesyloxy group.In this way, ecklonoquinone A (2), ecklonoquinone B (3), isoecklonoquinone A (43), and isoecklonoquinone B (44) were prepared.Their structures are based on X-ray analyses of ecklonoquinone-A leucoacetate (45) and the mesyloxy-substituted quinone 20.The reddish-violet dibenzodioxin-diquinone 49 was prepared from an intermediate of the iso-series.The parent compound 1 has been synthesized in yields better than 50percent from pyrocatechol and methyl 2,5-dioxo-2,5-dihydrobenzoate as oxidant and 2-methoxypyridin as catalyst.To rationalize the specific effect on the dimerisation step of the mesyloxy group, the intermediacy of 1,4-quinone monoacetals is proposed.This also applies to a proposed biogenetic scheme.