1019638-05-1

Basic information

• Product Name: tert-butyl (2S,4S)-4-{[4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinyl]carbonyl}-2-(1-pyrrolidinylcarbonyl)-1-pyrrolidinecarboxylate
• Synonyms: tert-butyl (2S,4S)-4-{[4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinyl]carbonyl}-2-(1-pyrrolidinylcarbonyl)-1-pyrrolidinecarboxylate
• CAS NO: 1019638-05-1
• Molecular Weight: 540.687
• Mol File: 1019638-05-1.mol

Chemical Properties

• CAS DataBase Reference: tert-butyl (2S,4S)-4-{[4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinyl]carbonyl}-2-(1-pyrrolidinylcarbonyl)-1-pyrrolidinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (2S,4S)-4-{[4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinyl]carbonyl}-2-(1-pyrrolidinylcarbonyl)-1-pyrrolidinecarboxylate(1019638-05-1)
• EPA Substance Registry System: tert-butyl (2S,4S)-4-{[4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinyl]carbonyl}-2-(1-pyrrolidinylcarbonyl)-1-pyrrolidinecarboxylate(1019638-05-1)

Safety Data

• Hazardous Substances Data: 1019638-05-1(Hazardous Substances Data)

Upstream product

• 306935-14-8 1-(3-phenyl-[1,2,4]thiadiazol-5-yl)piperazine 
• 898273-28-4 (3S,5S)-1-(tert-butoxycarbonyl)-5-(1-pyrrolidinylcarbonyl)-3-pyrrolidinecarboxylic acid 

Downstream Products

• 898273-33-1 1-(3-phenyl-1,2,4-thiadiazol-5-yl)-4-{[(3S,5S)-5-(1-pyrrolidinylcarbonyl)-3-pyrrolidinyl]carbonyl}piperazine monohydrochloride 

Relevant articles and documents

Design and synthesis of DPP-IV inhibitors lacking the electrophilic nitrile group

A series of (4β-substituted)-l-prolylpyrrolidine analogs lacking the electrophilic nitrile function were synthesized and their dipeptidyl peptidase IV (DPP-IV) inhibitory activity and duration of ex vivo activity were evaluated. Structural optimization of a N-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine analog 8, which was found by high-speed analog synthesis, was carried out to improve the potency and duration of action. A representative compound 26 was evaluated to assess its effect on the plasma glucose level after the oGTT (oral glucose tolerance test) in normal rats. Structure-activity relationships (SAR) are also presented.