1019858-67-3

Basic information

• Product Name: cyclomarin D
• CAS NO: 1019858-67-3
• Molecular Weight: 1013.29
• Mol File: 1019858-67-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: cyclomarin D(CAS DataBase Reference)
• NIST Chemistry Reference: cyclomarin D(1019858-67-3)
• EPA Substance Registry System: cyclomarin D(1019858-67-3)

Safety Data

• Hazardous Substances Data: 1019858-67-3(Hazardous Substances Data)

Upstream product

• 878807-58-0 3-iodo-1-(2-methylbut-3-en-2-yl)-1H-indole 
• 377073-09-1 1-(2-methylbut-3-en-2-yl)-1H-indole 
• 306776-02-3 1H-indole-3-carboxylic acid, 1-(1,1-dimethyl-2-propenyl) methyl ester 
• 753487-55-7 (2S,3R)-N-(tert-butyloxycarbonyl)-3-methoxyphenylalanine 
• 1009093-09-7 (2R,3R)-N-Boc-3-methoxy-1-O-(tert-butyldimethylsilyl)-phenylalaninol 
• 217661-62-6 [(1R,2R)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-2-hydroxy-2-phenyl-ethyl]-carbamic acid tert-butyl ester 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 35026-08-5 N-methyl-L-leucine methyl ester 

Relevant articles and documents

Total synthesis of cyclomarins A, C and D, marine cyclic peptides with interesting anti-tuberculosis and anti-malaria activities

Cyclomarins are cyclic heptapeptides containing four unusual amino acids. New synthetic protocols toward their synthesis have been developed, leading to the synthesis and biological evaluation of three natural occurring cyclomarins. Interestingly, cyclomarins address two completely different targets: Clp C1, a subunit of the caseinolytic protease of Mycobacterium tuberculosis (MTB), as well as PfAp3Ase of Plasmodium falciparum. Therefore, cyclomarins are interesting lead structures for the development of drugs against tuberculosis and malaria.