10199-61-8

Basic information

• Product Name: ETHYL 2-(1H-PYRAZOL-1-YL)ACETATE
• Synonyms: 1-(2-Ethoxy-2-oxoethyl)-1H-pyrazole;ETHYL 1H-PYRAZOLE-1-ACETATE;2-(1-pyrazolyl)acetic acid ethyl ester;2-pyrazol-1-ylacetic acid ethyl ester;ethyl 2-pyrazol-1-ylacetate;ethyl 2-pyrazol-1-ylethanoate;AKOS PAO-0921;ETHYL 2-(1H-PYRAZOL-1-YL)ACETATE
• CAS NO: 10199-61-8
• Molecular Formula: C₇H₁₀N₂O₂
• Molecular Weight: 154.17
• Mol File: 10199-61-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 236.9 °C at 760 mmHg
• Flash Point: 97 °C
• Appearance: /
• Density: 1.14 g/cm³
• Vapor Pressure: 0.0463mmHg at 25°C
• Refractive Index: 1.524
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ETHYL 2-(1H-PYRAZOL-1-YL)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-(1H-PYRAZOL-1-YL)ACETATE(10199-61-8)
• EPA Substance Registry System: ETHYL 2-(1H-PYRAZOL-1-YL)ACETATE(10199-61-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 10199-61-8(Hazardous Substances Data)

Usage

General Description

ETHYL 2-(1H-PYRAZOL-1-YL)ACETATE is a chemical compound with the molecular formula C8H10N2O2. It is a colorless liquid with a faint odor. ETHYL 2-(1H-PYRAZOL-1-YL)ACETATE is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a flavoring agent in the food industry. ETHYL 2-(1H-PYRAZOL-1-YL)ACETATE is known for its mild toxicity, and proper precautions should be taken when handling and storing this chemical.

InChI:InChI=1/C7H10N2O2/c1-2-11-7(10)6-9-5-3-4-8-9/h3-5H,2,6H2,1H3

Upstream product

• 288-13-1 NH-pyrazole 
• 105-39-5 chloroacetic acid ethyl ester 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 914490-03-2 2-(4-amino-pyrazol-1-yl)-N-phenyl-acetamide 
• 914490-01-0 2-(4-nitro-pyrazol-1-yl)-N-phenyl-acetamide 
• 501031-46-5 ethyl 3-(4-bromophenyl)-2-(1H-pyrazol-1-yl)propanoate 
• 6645-69-8 2-(4-nitro-1H-pyrazol-1-yl)acetic acid 
• 302561-36-0 benzhydrylidene-(5-pyrazol-1-ylmethyl-[1,3,4]thiadiazol-2-yl)-amine 
• 302561-23-5 [1-(2-Nitro-phenyl)-meth-(E)-ylidene]-(5-pyrazol-1-ylmethyl-[1,3,4]thiadiazol-2-yl)-amine 
• 302561-32-6 [1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-(5-pyrazol-1-ylmethyl-[1,3,4]thiadiazol-2-yl)-amine 
• 302561-19-9 [1-(2-Chloro-phenyl)-meth-(E)-ylidene]-(5-pyrazol-1-ylmethyl-[1,3,4]thiadiazol-2-yl)-amine 
• 302561-40-6 [1-Phenyl-eth-(E)-ylidene]-(5-pyrazol-1-ylmethyl-[1,3,4]thiadiazol-2-yl)-amine 
• 302561-29-1 [1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-(5-pyrazol-1-ylmethyl-[1,3,4]thiadiazol-2-yl)-amine 
• 302561-21-3 [1-(4-Chloro-phenyl)-meth-(E)-ylidene]-(5-pyrazol-1-ylmethyl-[1,3,4]thiadiazol-2-yl)-amine 
• 302561-27-9 [(E)-3-Phenyl-prop-2-en-(E)-ylidene]-(5-pyrazol-1-ylmethyl-[1,3,4]thiadiazol-2-yl)-amine 
• 302561-17-7 [1-Phenyl-meth-(E)-ylidene]-(5-pyrazol-1-ylmethyl-[1,3,4]thiadiazol-2-yl)-amine 
• 16034-48-3 pyrazol-1-yl-acetic acid 

Relevant articles and documents

Alkylation of pyrazoles with ethyl chloroacetate under phase-transfer catalysis and hydrolysis of the esters obtained

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7-OXO -6-(SULFOOXY)- 1,6-DIAZABICYCLO [3.2.1] OCTANE CONTAINING COMPOUNDS AND THEIR USE IN TREATMENT OF BACTERIAL INFECTIONS

Compounds of Formula (I) or a stereoisomer or a pharmaceutically acceptable salt thereof, their preparation, and use in treating a bacterial infection are disclosed.

Tetrazolylhydrazides as selective fragment-like inhibitors of the JumonjiC-domain-containing histone demethylase KDM4A

The JumonjiC-domain-containing histone demethylase 2A (JMJD2A, KDM4A) is a key player in the epigenetic regulation of gene expression. Previous publications have shown that both elevated and lowered enzyme levels are associated with certain types of cancer, and therefore the definite role of KDM4A in oncogenesis remains elusive. To identify a novel molecular starting point with favorable physicochemical properties for the investigation of the physiological role of KDM4A, we screened a number of molecules bearing an iron-chelating moiety by using two independent assays. In this way, we were able to identify 2-(1H-tetrazol-5-yl)acetohydrazide as a novel fragment-like lead structure with low relative molecular mass (Mr=142 Da), low complexity, and an IC50 value of 46.6 μm in a formaldehyde dehydrogenase (FDH)-coupled assay and 2.4 μm in an antibody-based assay. Despite its small size, relative selectivity against two other demethylases could be demonstrated for this compound. This is the first example of a tetrazole group as a warhead in JMJD demethylases. Anchor fragment: To develop non-promiscuous metalloenzyme inhibitors, a metal-complexing acetohydrazide group was integrated in a tetrazolyl fragment, which can be matured into a scaffold to promote further selectivity at the ligand backbone binding site of these emerging drug targets.