1019907-06-2

Basic information

• Product Name: 2-[1-(4-bromophenyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl]-2-oxoacetic acid
• CAS NO: 1019907-06-2
• Molecular Weight: 420.26
• Mol File: 1019907-06-2.mol

Chemical Properties

• CAS DataBase Reference: 2-[1-(4-bromophenyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl]-2-oxoacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[1-(4-bromophenyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl]-2-oxoacetic acid(1019907-06-2)
• EPA Substance Registry System: 2-[1-(4-bromophenyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl]-2-oxoacetic acid(1019907-06-2)

Safety Data

• Hazardous Substances Data: 1019907-06-2(Hazardous Substances Data)

Upstream product

• 1019906-95-6 ethyl 2-[1-(4-bromophenyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl]-2-oxoacetate 

Downstream Products

• 1019907-58-4 C₂₃H₂₅BrN₂O₄ 
• 1019907-30-2 C₂₄H₂₇BrN₂O₄ 
• 1019907-42-6 C₂₃H₂₅BrN₂O₅ 
• 1019907-18-6 C₂₃H₂₇BrN₂O₄ 

Relevant articles and documents

Synthesis and anticonvulsant evaluation of N-substituted isoquinoline AMPA receptor antagonists

In our previous studies a ligand-based approach led to the identification of noncompetitive AMPA receptor antagonists containing isoquinoline scaffold. In an attempt to perform a systematic SAR study, we synthesized new N-substituted-isoquinolines bearing the most salient features described by our 3D pharmacophore model. All compounds were screened against audiogenic seizures and some derivatives showed anticonvulsant properties. Compound 24, the most active of the series, was also tested in vitro using the patch-clamp technique and proved to antagonize AMPA-mediated effects.