1019996-86-1

Basic information

• Product Name: 1-Nitro-4-[4-(trifluoroMethoxy)phenyl]benzene
• Synonyms: 1-Nitro-4-[4-(trifluoroMethoxy)phenyl]benzene
• CAS NO: 1019996-86-1
• Molecular Formula: C₁₃H₈F₃NO₃
• Molecular Weight: 283.2027296
• Mol File: 1019996-86-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 337.8±42.0 °C(Predicted)
• Appearance: /
• Density: 1.368±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-Nitro-4-[4-(trifluoroMethoxy)phenyl]benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Nitro-4-[4-(trifluoroMethoxy)phenyl]benzene(1019996-86-1)
• EPA Substance Registry System: 1-Nitro-4-[4-(trifluoroMethoxy)phenyl]benzene(1019996-86-1)

Safety Data

• Hazardous Substances Data: 1019996-86-1(Hazardous Substances Data)

Usage

General Description

1-Nitro-4-[4-(trifluoroMethoxy)phenyl]benzene, also known as 2-(4-nitrophenyl)-1,1,1-trifluoro-4-methoxybenzene, is a chemical compound with the molecular formula C13H8F3NO3. It is a nitrobenzene derivative with a trifluoromethoxy group and a nitro group attached to a phenyl ring. 1-Nitro-4-[4-(trifluoroMethoxy)phenyl]benzene is used in organic synthesis and can be a precursor to other chemicals or pharmaceuticals. It is also known for its potential use as a pesticide or insecticide. Overall, 1-Nitro-4-[4-(trifluoroMethoxy)phenyl]benzene has diverse applications in various industries such as pharmaceuticals, agrochemicals, and organic chemistry.

Upstream product

• 586-78-7 para-nitrophenyl bromide 
• 139301-27-2 4-trifluoromethoxyphenylboronic acid 
• 636-98-6 p-nitrobenzene iodide 

Downstream Products

• 728919-14-0 4'-(trifluoromethoxy)-1,1'-biphenyl-4-amine 
• 1019996-99-6 4-[4-(tert-butyl)phenyl]amino-4'-(trifluoromethoxy)biphenyl 
• 1019996-90-7 methyl N-(3-methylbenzyl)-N-[4'-(trifluoromethoxy)biphenyl-4-yl]oxamate 

Relevant articles and documents

Discovery of Biphenyl-Sulfonamides as Novel β- N-Acetyl- d -Hexosaminidase Inhibitors via Structure-Based Virtual Screening

Novel insecticidal targets are always in demand due to the development of resistance. OfHex1, a β-N-acetyl-d-hexosaminidase identified in Ostrinia furnacalis (Asian corn borer), is involved in insect chitin catabolism and has proven an ideal target for insecticide development. In this study, structure-based virtual screening, structure simplification, and biological evaluation are used to show that compounds with a biphenyl-sulfonamide skeleton have great potential as OfHex1 inhibitors. Specifically, compounds 10k, 10u, and 10v have Ki values of 4.30, 3.72, and 4.56 μM, respectively, and thus, they are more potent than some reported nonglycosyl-based inhibitors such as phlegmacin B1 (Ki = 26 μM), berberine (Ki = 12 μM), 2 (Ki = 11.2 μM), and 3 (Ki = 28.9 μM). Furthermore, inhibitory kinetic assessments reveal that the target compounds are competitive inhibitors with respect substrate, and based on toxicity predictions, most of them have potent drug properties. The obtained results indicate that the biphenyl-sulfonamide skeleton characterized by simple chemical structure, synthetic tractability, potent activity, and low toxicity has potential for further development in pest management targeting OfHex1.

PAI-1 INHIBITOR

The compound represented by the following formula (I) and the like have PAI-1 inhibition activity; wherein: R1 represents a C6-10 aryl group which may be substituted or the like; T represents a single bond or the like; m represents 0

In vitro PAI-1 inhibitory activity of oxalamide derivatives

A number of oxalamide derivatives have been synthesized and evaluated for PAI-1 inhibitory activity. In vitro PAI-1 inhibitory activities of oxalamide derivatives are evaluated by chromogenic assay. Few compounds have shown significant PAI-1 inhibitory activity.