1020002-08-7Relevant academic research and scientific papers
Regio-and enantioselective catalytic cyclization of pyrroles onto N-acyliminium lons
Raheem, Izzat T.,Thiara, Parvinder S.,Jacobsen, Eric N.
, p. 1577 - 1580 (2008)
The regio- and enantioselective cyclization of pyrroles onto N-acyliminium ions generated in situ from hydroxylactams is reported. Modest to excellent ee's and yields are obtained in these novel Pictet-Spengler-type reactions with a chiral thiourea-pyrrole catalyst. Useful synthetic transformations of the versatile pyrroloindolizidinone and pyrroloquinolizidinone products are presented.
