1020035-04-4

Basic information

• Product Name: 6-Methylimidazo[1,2-a]pyrimidine-3-carboxylic acid
• Synonyms: 6-Methylimidazo[1,2-a]pyrimidine-3-carboxylic acid
• CAS NO: 1020035-04-4
• Molecular Formula: C8H7N3O2
• Molecular Weight: 177.16008
• Mol File: 1020035-04-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-Methylimidazo[1,2-a]pyrimidine-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methylimidazo[1,2-a]pyrimidine-3-carboxylic acid(1020035-04-4)
• EPA Substance Registry System: 6-Methylimidazo[1,2-a]pyrimidine-3-carboxylic acid(1020035-04-4)

Safety Data

• Hazardous Substances Data: 1020035-04-4(Hazardous Substances Data)

Upstream product

• 50840-23-8 5-methylpyrimidin-2-amine 
• 1339175-99-3 ethyl 6-methylimidazo[1,2-a]pyrimidine-3-carboxylate 

Relevant articles and documents

Systematic structure modifications of imidazo[1,2-a]pyrimidine to reduce metabolism mediated by aldehyde oxidase (AO)

N-{trans-3-[(5-Cyano-6-methylpyridin-2-yl)oxy]-2,2,4,4- tetramethylcyclobutyl}imidazo[1,2-a]pyrimidine-3-carboxamide (1) was recently identified as a full antagonist of the androgen receptor, demonstrating excellent in vivo tumor growth inhibition in castration-resistant prostate cancer (CRPC). However, the imidazo[1,2-a]pyrimidine moiety is rapidly metabolized by aldehyde oxidase (AO). The present paper describes a number of medicinal chemistry strategies taken to avoid the AO-mediated oxidation of this particular system. Guided by an AO protein structure-based model, our investigation revealed the most probable site of AO oxidation and the observation that altering the heterocycle or blocking the reactive site are two of the more effective strategies for reducing AO metabolism. These strategies may be useful for other drug discovery programs.