1020042-77-6 Usage
Description
8-Chloro-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one is a heterocyclic chemical compound characterized by a molecular formula of C6H4ClN3O. It features a triazolopyridine ring system with a chlorine atom at the 8th position, which contributes to its unique properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
8-Chloro-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one is used as a potent inhibitor of the enzyme TRPV1, which plays a crucial role in pain sensation and inflammation. Its ability to inhibit TRPV1 makes it a promising candidate for the treatment of pain, neurological disorders, and inflammatory conditions.
Used in Medicinal Chemistry and Drug Discovery:
8-Chloro-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one's unique structure and properties make it a valuable asset in the field of medicinal chemistry and drug discovery. Researchers can utilize its characteristics to develop new drugs or improve existing ones, potentially leading to more effective treatments for various conditions.
Used in Pain Management:
8-Chloro-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one is used as an analgesic agent for the management of pain. Its TRPV1 inhibitory properties allow it to alleviate pain by modulating the pain signaling pathways, providing relief to patients suffering from chronic or acute pain.
Used in Neurological Disorder Treatment:
8-Chloro-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one's potential use in the treatment of neurological disorders stems from its ability to modulate the TRPV1 enzyme, which is implicated in various neurological conditions. By targeting this enzyme, 8-Chloro-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one may help alleviate symptoms and improve the quality of life for patients with neurological disorders.
Used in Inflammatory Condition Management:
Inflammation is a common feature of many diseases and conditions. As a TRPV1 inhibitor, 8-Chloro-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one can be used to manage inflammatory conditions by reducing the inflammatory response, thus providing relief and potentially improving the overall health of patients.
Check Digit Verification of cas no
The CAS Registry Mumber 1020042-77-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,0,0,4 and 2 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1020042-77:
(9*1)+(8*0)+(7*2)+(6*0)+(5*0)+(4*4)+(3*2)+(2*7)+(1*7)=66
66 % 10 = 6
So 1020042-77-6 is a valid CAS Registry Number.
1020042-77-6Relevant articles and documents
Facile and efficient synthesis and herbicidal activity determination of novel 1,2,4-triazolo[4,3-a]pyridin-3(2H)-one derivatives via microwave irradiation
Liu, Xing-Hai,Zhai, Zhi-Wen,Xu, Xiao-Yan,Yang, Ming-Yan,Sun, Zhao-Hui,Weng, Jian-Quan,Tan, Cheng-Xia,Chen, Jie
, p. 5524 - 5528 (2015)
A series of novel 1,2,4-triazolo[4,3-a]pyridin-3(2H)-one derivatives were synthesized and identified by 1H NMR, single crystal X-ray diffraction, elemental analysis or HRMS, and their herbicidal activities were determined at different concentrations. It was found that some of the title compounds possess high herbicidal activity. Furthermore, DFT calculation was used to study the SAR.
The Base-Promoted Annulation of 2-Hydrazinyl Pyridine and CO2 toward Triazolones
Wu, Xiaopeng,Sun, Song,Wang, Bingbing,Cheng, Jiang
supporting information, p. 3855 - 3859 (2017/11/15)
A base-promoted annulation of 2-hydrazinyl pyridine and atmospheric pressure of CO2 has been developed in the presence of silane as reducing reagent, affording a series of triazolones in moderate to excellent yields. CO2 served as a carbonyl source in this transfomation. Moreover, benzamidrazones also worked well under this procedure. Thus, it represents a green, sustainable and straightforward pathway to access triazolone frameworks. (Figure presented.).
