1020067-62-2Relevant academic research and scientific papers
Synthesis of 2′-O-α-d-ribofuranosyladenosine, monomeric unit of poly(ADP-ribose)
Mikhailov, Sergey N.,Kulikova, Irina V.,Nauwelaerts, Koen,Herdewijn, Piet
, p. 2871 - 2876 (2008)
The first chemical synthesis of 2′-O-α-d-ribofuranosyladenosine, monomeric unit of poly(ADP-ribose), has been achieved starting from 3′,5′-O-bis protected 9-(2-O-α-d-arabinofuranosyl-β-d-ribofuranosyl)-adenine. Configurational inversion of 2′-hydroxyl gro
Synthesis of disaccharide nucleoside analogues as potential poly(ADP-ribose) polymerase-1 inhibitors
Zheng, Meng,Mex, Martin,G?tz, Kathrin H.,Marx, Andreas
, p. 8904 - 8907 (2018/12/10)
Poly(ADP-ribose) polymerase-1 (PARP-1) is an important target in cancer therapy. We present the synthesis of novel disaccharide nucleoside analogues that resemble the central motif of poly(ADP-ribose) and test their inhibitory effects on human PARP-1. Some compounds show inhibition of enzymatic activity in vitro and thus might be interesting for further investigations.
