1020075-73-3Relevant academic research and scientific papers
Synthesis of naphthalenes through three-component coupling of alkynes, fischer carbene complexes, and benzaldehyde hydrazones via isoindole intermediates
Duan, Shaofeng,Sinha-Mahapatra, Dilip K.,Herndon, James W.
, p. 1541 - 1544 (2008)
The synthesis of naphthalene derivatives through three-component coupling of 2-alkynylbenzaldehyde hydrazones with carbene complexes and electron-deficient alkynes has been examined. The reaction involves formation of an isoindole derivative, followed by intramolecular Diels-Alder reaction, followed by nitrene extrusion. The reaction was highly regioselective using unsymmetrical alkynes.
