10201-21-5

Basic information

• Product Name: 2-aMino-6,7,7-triMethyl-7,8-dihydropteridin-4(3H)-one
• Synonyms: 2-aMino-6,7,7-triMethyl-7,8-dihydropteridin-4(3H)-one;2-aMino-6,7,7-triMethyl-4a,7,8,8a-tetrahydropteridin-4(3H)-one
• CAS NO: 10201-21-5
• Molecular Formula: C₉H₁₃N₅O
• Molecular Weight: 207.23242
• Mol File: 10201-21-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-aMino-6,7,7-triMethyl-7,8-dihydropteridin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-aMino-6,7,7-triMethyl-7,8-dihydropteridin-4(3H)-one(10201-21-5)
• EPA Substance Registry System: 2-aMino-6,7,7-triMethyl-7,8-dihydropteridin-4(3H)-one(10201-21-5)

Safety Data

• Hazardous Substances Data: 10201-21-5(Hazardous Substances Data)

Usage

General Description

2-Amino-6,7,7-trimethyl-7,8-dihydropteridin-4(3H)-one is a chemical compound that belongs to the pteridine class of compounds. It is also known as 7,8-dihydro-6-methyl-7,8-dimethylpterin-4(3H)-one. 2-aMino-6,7,7-triMethyl-7,8-dihydropteridin-4(3H)-one has a pteridine structure with an amino group attached at the 2-position. It is a yellowish-brown solid that is insoluble in water but soluble in organic solvents. This chemical is a precursor for the synthesis of folic acid, a vital nutrient that is essential for various biological processes in the body. Additionally, it is used as a standard for high-performance liquid chromatography (HPLC) and mass spectrometry (MS) analyses in the field of biochemistry.

Upstream product

• 102223-03-0 2-amino-6-<3-hydroxyimino-2-methyl-4-(2,4,5-trichlorophenoxy)butan-2-ylamino>-5-nitropyrimidin-4(3H)-one 
• 10201-18-0 2-amino-4-(1',1'-dimethylacetonyl)amino-6-hydroxy-5-nitro pyrimidine 
• 10201-16-8 3-amino-3-methylbutan-2-one semicarbazone hydrochloride 
• 13325-14-9 3-amino-3-methylbutan-2-ol 
• 10201-18-0 2-amino-6-(1,1-dimethylacetonylamino)-5-nitropyrimidin-4(3H)-one 
• 102223-05-2 2-amino-7,8-dihydro-7,7-dimethyl-6-(2,4,5-trichlorophenoxymethyl)pteridin-4(3H)-one 
• 102223-00-7 3-amino-3-methyl-1-(2,4,5-trichlorophenoxy)butan-2-one oxime hydrochloride 
• 101211-10-3 2-amino-6-(1,1-dimethylacetonylamino)-5-nitropyrimidin-4(3H)-one semicarbazone 
• 37557-72-5 3-benzamido-3-methylbutan-2-one 
• 37557-71-4 3-benzamido-3-methylbutan-2-ol 
• 10201-10-2 3-azido-3-methylbutan-2-one 
• 2648-71-7 3-bromo-3-methyl-2-butanone 

Downstream Products

• 490-79-9 2,5-dihydroxybenzoic acid. 
• 53640-85-0 2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carbaldehyde 

Relevant articles and documents

HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS

The disclosure provides linked purine pterin compounds of Formula I that are novel inhibitors of HPPK, a kinase responsible for an essential step in the biosynthesis of folic acid. (Formula I) The variables, e.g., A1-A3, R1-R4, B1-B2, and L1 are defined in the disclosure. These linked purine pterin inhibitors bind to HPPK with high affinity and specificity. Pharmaceutical compositions containing the HPPK inhibitors and methods of treating a bacterial infection in a patient with one or more of the HPPK inhibitors of the disclosure are also provided.

Specific Inhibitors in Vitamin Biosynthesis. Part 7. Syntheses of Blocked 7,8-Dihydropteridines via &α-Amino Ketones

The synthesis of 15 blocked 7,8-dihydropteridines is described in which the pyrazine ring is built from a derivative of an α-amino ketone.Three routes to the amino ketones based upon amino acids, nitrosyl chloride addition to alkenes, and nitro alcohols are discussed.The compounds synthesised are inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase , an enzyme in the pathway leading to dihydrofolate, and the inhibitory potencies of the compounds are discussed in the light of a hypothetical active site model for the enzyme.