10201-73-7Relevant articles and documents
Improved procedures for preparation of 4-hydroxy- and 2-amemo-4-methoxy-2-aminopyridines
Sundberg, Richard J.,Jiang, Songchun
, p. 117 - 122 (1997)
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A convenient synthetic route to substituted pyrrolo[2,3-b]pyridines via a novel ethylene-bridged compound
Wilding, Birgit,Vidovic, Carina,Klempier, Norbert
, p. 6606 - 6609 (2015)
A convenient synthetic route to 4-substituted pyrrolo[2,3-b]pyridines is presented. The novel ethylene bridged compound 1,2-bis(4-azidopyrrolo[2,3-b]pyridinyl)ethene was prepared and further derivatized. The novel synthesis was applied in the preparation of 3-cyano-4-hydroxypyrrolo[2,3-b]pyridine.
BCR-ABL TYROSINE-KINASE LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME
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Paragraph 00592; 00603; 00604, (2015/07/23)
Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. invivo) to form a multimer (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding sites on a Bcr-Abl tyrosine kinase.
Consecutive gold(I)-catalyzed cyclization reactions of o -(buta-1,3-diyn-1-yl-)-substituted N-aryl ureas: A one-pot synthesis of pyrimido[1,6- a ]indol-1(2 H)-ones and related systems
Sharp, Phillip P.,Banwell, Martin G.,Renner, Jens,Lohmann, Klaas,Willis, Anthony C.
, p. 2616 - 2619 (2013/07/11)
Treatment of readily available o-(buta-1,3-diyn-1-yl-)-substituted N-aryl ureas such as 1 with the Au(I)-catalyst 11 affords, via a twofold cyclization process, the isomeric pyrimido[1,6-a]indol-1(2H)-one 3 in good yield.
