1020104-56-6Relevant articles and documents
Discovery of novel cobactin-t based matrix metalloproteinase inhibitors via a ring closing metathesis strategy
Wilson, Lawrence J.,Wang, Bingbing,Yang, Shyh-Ming,Scannevin, Robert H.,Burke, Sharon L.,Karnachi, Prabha,Rhodes, Kenneth J.,Murray, William V.
, p. 6485 - 6490 (2011/12/04)
The discovery of potent N-hydroxyl caprolactam matrix metalloproteinase (MMP) inhibitors (6) based on the natural product Cobactin-T (2) is described. The synthetic method, which utilizes the ring closing metathesis reaction, is compatible to provide comp